Browsing by Author "Sachse, Martin"

Now showing items 1-3 of 3

    • Middle East respiratory coronavirus (MERS-CoV) internalized by llama alveolar macrophages does not result in virus replication or induction of pro-inflammatory cytokines 

      Rodon, Jordi; Sachse, Martin; Te, Nigeer; Segalés, Joaquim; Bensaid, Albert; Risco, Cristina; Vergara-Alert, Júlia (Microbes and Infection, 2024-03) Sanitat Animal
      Severe Middle East respiratory syndrome (MERS) is characterized by massive infiltration of immune cells in lungs. MERS-coronavirus (MERS-CoV) replicates in vitro in human macrophages, inducing high ...

    • Unraveling the antiviral activity of plitidepsin against SARS-CoV-2 by subcellular and morphological analysis 

      Sachse, Martin; Tenorio, Raquel; Fernández de Castro, Isabel; Muñoz-Basagoiti, Jordana; Perez-Zsolt, Daniel; Raïch-Regué, Dàlia; Rodon, Jordi; Losada, Alejandro; Avilés, Pablo; Cuevas, Carmen; Paredes, Roger; Segalés, Joaquim; Clotet, Bonaventura; Vergara-Alert, Júlia; Izquierdo-Useros, Nuria; Risco, Cristina (Antiviral Research, 2022-02-26) Sanitat Animal
      The pandemic caused by the new coronavirus SARS-CoV-2 has made evident the need for broad-spectrum, efficient antiviral treatments to combat emerging and re-emerging viruses. Plitidepsin is an antitumor ...

    • β-Cyclodextrins as affordable antivirals to treat coronavirus infection 

      Raïch-Regué, Dalia; Tenorio, Raquel; Fernández de Castro, Isabel; Tarrés Freixas, Ferran; Sachse, Martin; Perez-Zsol, Daniel; Muñoz Basagoiti, Jordana; Fernández-Sánchez, Sara Y.; Gallemí, Marçal; Ortega-González, Paula; Fernández-Oliva, Alberto; Gabaldón, José A.; Nuñez-Delicado, Estrella; Casas, Josefina; Roca, Núria; Cantero, Guillermo; Pérez, Mónica; Usai, Carla; Lorca-Oró, Cristina; Vergara-Alert, Júlia; Segalés, Joaquim; Carrillo, Jorge; Blanco, Julià; Clotet Sala, Bonaventura; Cerón-Carrasco, José P.; Izquierdo-Useros, Nuria; Risco, Cristina (Biomedicine and Pharmacotherapy, 2023-06-08) Sanitat Animal
      The SARS-CoV-2 pandemic made evident that there are only a few drugs against coronavirus. Here we aimed to identify a cost-effective antiviral with broad spectrum activity and high safety profile. ...