Animal models for COVID-19
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Author
Muñoz-Fontela, César
Dowling, William E.
Funnell, Simon G. P.
Gsell, Pierre-S.
Riveros-Balta, A. Ximena
Albrecht, Randy A.
Andersen, Hanne
Baric, Ralph S.
Carroll, Miles W.
Cavaleri, Marco
Qin, Chuan
Crozier, Ian
Dallmeier, Kai
de Waal, Leon
de Wit, Emmie
Delang, Leen
Dohm, Erik
Duprex, W. Paul
Falzarano, Darryl
Finch, Courtney L.
Frieman, Matthew B.
Graham, Barney S.
Gralinski, Lisa E.
Guilfoyle, Kate
Haagmans, Bart L.
Hamilton, Geraldine A.
Hartman, Amy L.
Herfst, Sander
Kaptein, Suzanne J. F.
Klimstra, William B.
Knezevic, Ivana
Krause, Philip R.
Kuhn, Jens H.
Le Grand, Roger
Lewis, Mark G.
Liu, Wen-Chun
Maisonnasse, Pauline
McElroy, Anita K.
Munster, Vincent
Oreshkova, Nadia
Rasmussen, Angela L.
Rocha-Pereira, Joana
Rockx, Barry
Rodríguez, Estefanía
Rogers, Thomas F.
Salguero, Francisco J.
Schotsaert, Michael
Stittelaar, Koert J.
Thibaut, Hendrik Jan
Tseng, Chien-Te
Vergara-Alert, Júlia
Beer, Martin
Brasel, Trevor
Chan, Jasper F. W.
García-Sastre, Adolfo
Neyts, Johan
Perlman, Stanley
Reed, Douglas S.
Richt, Juergen A.
Roy, Chad J.
Vasan, Seshadri S.
Henao-Restrepo, Ana María
Barouch, Dan H.
Publication date
2020-09-23ISSN
0028-0836
Abstract
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the aetiological
agent of coronavirus disease 2019 (COVID-19), an emerging respiratory infection
caused by the introduction of a novel coronavirus into humans late in 2019 (frst
detected in Hubei province, China). As of 18 September 2020, SARS-CoV-2 has spread
to 215 countries, has infected more than 30 million people and has caused more than
950,000 deaths. As humans do not have pre-existing immunity to SARS-CoV-2, there
is an urgent need to develop therapeutic agents and vaccines to mitigate the current
pandemic and to prevent the re-emergence of COVID-19. In February 2020, the World
Health Organization (WHO) assembled an international panel to develop animal
models for COVID-19 to accelerate the testing of vaccines and therapeutic agents.
Here we summarize the fndings to date and provides relevant information for
preclinical testing of vaccine candidates and therapeutic agents for COVID-19.
Document Type
Article
Document version
Accepted version
Language
English
Subject (CDU)
619 - Veterinary science
Pages
31
Publisher
Nature Research
Is part of
Nature
Citation
Muñoz-Fontela, César, William E. Dowling, Simon G. P. Funnell, Pierre-S. Gsell, A. Ximena Riveros-Balta, Randy A. Albrecht, and Hanne Andersen et al. 2020. "Animal Models For COVID-19". Nature 586 (7830): 509-515. doi:10.1038/s41586-020-2787-6.
Program
Sanitat Animal
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Copyright © Springer Nature Limited 2020