Describing variability in pig genes involved in coronavirus infections for a One Health perspective in conservation of animal genetic resources
Visualitza/Obre
Autor/a
Bovo, Samuele
Schiavo, Giuseppina
Ribani, Anisa
Utzeri, Valerio J.
Taurisano, Valeria
Ballan, Mohamad
Muñoz, Maria
Alves, Estefania
Araujo, Jose P.
Bozzi, Riccardo
Charneca, Rui
Di Palma, Federica
Djurkin Kušec, Ivona
Etherington, Graham
Fernandez, Ana I.
García, Fabián
García-Casco, Juan
Karolyi, Danijel
Gallo, Maurizio
Martins, José Manuel
Mercat, Marie-José
Núñez, Yolanda
Radović, Čedomir
Razmaite, Violeta
Riquet, Juliette
Savić, Radomir
Škrlep, Martin
Usai, Graziano
Zimmer, Christoph
Ovilo, Cristina
Fontanesi, Luca
Data de publicació
2021-02-09ISSN
2045-2322
Resum
Coronaviruses silently circulate in human and animal populations, causing mild to severe diseases. Therefore, livestock are important components of a “One Health” perspective aimed to control these viral infections. However, at present there is no example that considers pig genetic resources in this context. In this study, we investigated the variability of four genes (ACE2, ANPEP and DPP4 encoding for host receptors of the viral spike proteins and TMPRSS2 encoding for a host proteinase) in 23 European (19 autochthonous and three commercial breeds and one wild boar population) and two Asian Sus scrofa populations. A total of 2229 variants were identified in the four candidate genes: 26% of them were not previously described; 29 variants affected the protein sequence and might potentially interact with the infection mechanisms. The results coming from this work are a first step towards a “One Health” perspective that should consider conservation programs of pig genetic resources with twofold objectives: (i) genetic resources could be reservoirs of host gene variability useful to design selection programs to increase resistance to coronaviruses; (ii) the described variability in genes involved in coronavirus infections across many different pig populations might be part of a risk assessment including pig genetic resources.
Tipus de document
Article
Versió del document
Versió publicada
Llengua
Anglès
Matèries (CDU)
619 - Veterinària
Pàgines
14
Publicat per
Nature Research
Publicat a
Scientific Reports
Citació
Bovo, Samuele, Giuseppina Schiavo, Anisa Ribani, Valerio J. Utzeri, Valeria Taurisano, Mohamad Ballan, and Maria Muñoz et al. 2021. "Describing Variability In Pig Genes Involved In Coronavirus Infections For A One Health Perspective In Conservation Of Animal Genetic Resources". Scientific Reports 11 (1). doi:10.1038/s41598-021-82956-0.
Número de l'acord de la subvenció
EC/H2020/634476/EU/DIVERSITY OF LOCAL PIG BREEDS AND PRODUCTION SYSTEMS FOR HIGH QUALITY TRADITIONAL PRODUCTS AND SUSTAINABLE PORK CHAINS/TREASURE
EC/COST/CA15112/EU/Functional Annotation of Animal Genomes-European network/FAANG-Europe
EC/H2020/831644/EU/EOSCsecretariat.eu/EOSCsecretariat.eu
EC/ / /EU/Application of animal genomics and data mining to predict and monitor novel coronavirus potential infections/VirAnimalOne
Programa
Genètica i Millora Animal
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