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dc.contributor.authorChrun, Tiphany
dc.contributor.authorLacôte, Sandra
dc.contributor.authorUrien, Céline
dc.contributor.authorJouneau, Luc
dc.contributor.authorBarc, Céline
dc.contributor.authorBouguyon, Edwige
dc.contributor.authorContreras, Vanessa
dc.contributor.authorFerrier-Rembert, Audrey
dc.contributor.authorPeyrefitte, Christophe N.
dc.contributor.authorBusquets, Nuria
dc.contributor.authorVidal, Enric
dc.contributor.authorPujols, Joan
dc.contributor.authorMarianneau, Philippe
dc.contributor.authorSchwartz-Cornil, Isabelle
dc.contributor.otherProducció Animalca
dc.date.accessioned2019-02-28T14:11:11Z
dc.date.available2019-02-28T14:11:11Z
dc.date.issued2018-04-20
dc.identifier.citationChrun, Tiphany, Sandra Lacôte, Céline Urien, Luc Jouneau, Céline Barc, Edwige Bouguyon, and Vanessa Contreras et al. 2018. "A Rift Valley Fever Virus Gn Ectodomain-Based DNA Vaccine Induces A Partial Protection Not Improved By APC Targeting". Npj Vaccines 3 (1). Springer Nature. doi:10.1038/s41541-018-0052-x.ca
dc.identifier.issn2059-0105ca
dc.identifier.urihttp://hdl.handle.net/20.500.12327/210
dc.description.abstractRift Valley fever virus, a phlebovirus endemic in Africa, causes serious diseases in ruminants and humans. Due to the high probability of new outbreaks and spread to other continents where competent vectors are present, vaccine development is an urgent priority as no licensed vaccines are available outside areas of endemicity. In this study, we evaluated in sheep the protective immunity induced by DNA vaccines encoding the extracellular portion of the Gn antigen which was either or not targeted to antigen-presenting cells. The DNA encoding untargeted antigen was the most potent at inducing IgG responses, although not neutralizing, and conferred a significant clinical and virological protection upon infectious challenge, superior to DNA vaccines encoding the targeted antigen. A statistical analysis of the challenge parameters supported that the anti-eGn IgG, rather than the T-cell response, was instrumental in protection. Altogether, this work shows that a DNA vaccine encoding the extracellular portion of the Gn antigen confers substantial—although incomplete—protective immunity in sheep, a natural host with high preclinical relevance, and provides some insights into key immune correlates useful for further vaccine improvements against the Rift Valley fever virus.ca
dc.format.extent13ca
dc.language.isoengca
dc.publisherNature Researchca
dc.relation.ispartofnpj Vaccinesca
dc.rightsAttribution 4.0 Internationalca
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
dc.titleA Rift Valley fever virus Gn ectodomain-based DNA vaccine induces a partial protection not improved by APC targetingca
dc.typeinfo:eu-repo/semantics/articleca
dc.description.versionreprintca
dc.embargo.termscapca
dc.identifier.doihttps://doi.org/10.1038/s41541-018-0052-xca
dc.contributor.groupSanitat Animalca


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Except where otherwise noted, this item's license is described as http://creativecommons.org/licenses/by/4.0/