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dc.contributor.authorHuang, Wan‐Yi
dc.contributor.authorWang, Ya‐Pei
dc.contributor.authorMahmmod, Yasser S.
dc.contributor.authorWang, Jun‐Jie
dc.contributor.authorLiu, Tang‐Hui
dc.contributor.authorZheng, Yu‐Xiang
dc.contributor.authorZhou, Xue
dc.contributor.authorZhang, Xiu‐Xiang
dc.contributor.authorYuan, Zi‐Guo
dc.contributor.otherProducció Animalca
dc.date.accessioned2019-04-02T14:15:49Z
dc.date.available2019-12-04T23:01:13Z
dc.date.issued2018-12-04
dc.identifier.citationHuang, Wan‐Yi, Ya‐Pei Wang, Yasser S. Mahmmod, Jun‐Jie Wang, Tang‐Hui Liu, Yu‐Xiang Zheng, Xue Zhou, Xiu‐Xiang Zhang, and Zi‐Guo Yuan. 2019. "A Double‐Edged Sword: Complement Component 3 In Toxoplasma Gondii Infection". PROTEOMICS 19 (3): 1800271. Wiley. doi:10.1002/pmic.201800271.ca
dc.identifier.issn1615-9853ca
dc.identifier.urihttp://hdl.handle.net/20.500.12327/231
dc.description.abstractSprague Dawley rats and Kunming (KM) mice are artificially infected with type II Toxoplasma gondii strain Prugniaud (Pru) to generate toxoplasmosis, which is a fatal disease mediated by T. gondii invasion of the central nervous system (CNS) by unknown mechanisms. The aim is to explore the mechanism of differential susceptibility of mice and rats to T. gondii infection. Therefore, a strategy of isobaric tags for relative and absolute quantitation (iTRAQ) is established to identify differentially expressed proteins (DEPs) in the rats’ and the mice's brains compared to the healthy groups. In KM mice, which is susceptible to T. gondii infection, complement component 3 (C3) is upregulated and the tight junction (TJ) pathway shows a disorder. It is presumed that T. gondii‐stimulated C3 disrupts the TJ of the blood–brain barrier in the CNS. This effect allows more T. gondii passing to the brain through the intercellular space.ca
dc.format.extent34ca
dc.language.isoengca
dc.publisherWileyca
dc.relation.ispartofProteomicsca
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internationalca
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.titleA double‐edged sword: Complement component 3 in toxoplasma gondii infectionca
dc.typeinfo:eu-repo/semantics/articleca
dc.description.versionpostprintca
dc.rights.accessLevelinfo:eu-repo/semantics/openAccess
dc.identifier.doihttps://doi.org/10.1002/pmic.201800271ca
dc.contributor.groupSanitat Animalca


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