A Roadmap for Hazard Monitoring and Risk Assessment of Marine Biotoxins on the Basis of Chemical and Biological Test Systems
Visualitza/Obre
Autor/a
Daneshian, Mardas
Botana, Luis M.
Bottein, Marie-Yasmine Dechraoui
Buckland, Gemma
Dennison, Ngaire
Dickey, Robert W.
Fessard, Valérie
Hartung, Thomas
Humpage, Andrew
Leist, Marcel
Molgó, Jordi
Quilliam, Michael A.
Rovida, Costanza
Suarez-Isla, Benjamin A.
Tubaro, Aurelia
Wagner, Kristina
Zoller, Otmar
Dietrich, Daniel
Data de publicació
2013-11-01ISSN
1868-596X
Resum
Aquatic food accounts for over 40% of global animal food products, and the potential contamination with toxins of algal origin – marine biotoxins – poses a health threat for consumers. The gold standards to assess toxins in aquatic food have traditionally been in vivo methods, i.e., the mouse as well as the rat bioassay. Besides ethical concerns, there is also a need for more reliable test methods because of low inter-species comparability, high intra-species variability, the high number of false positive and negative results as well as questionable extrapolation of quantitative risk to humans. For this reason, a transatlantic group of experts in the field of marine biotoxins was convened from academia and regulatory safety authorities to discuss future approaches to marine biotoxin testing. In this report they provide a background on the toxin classes, on their chemical characterization, the epidemiology, on risk assessment and management, as well as on their assumed mode of action. Most importantly, physiological functional assays such as in vitro bioassays and also analytical techniques, e.g., liquid chromatography coupled mass spectrometry (LC-MS), as substitutes for the rodent bioassay are reviewed. This forms the basis for recommendations on methodologies for hazard monitoring and risk assessment, establishment of causality of intoxications in human cases, a roadmap for research and development of human-relevant functional assays, as well as new approaches for a consumer directed safety concept.
Tipus de document
Article
Versió del document
Versió publicada
Llengua
Anglès
Matèries (CDU)
574 - Ecologia general i biodiversitat
Pàgines
59
Publicat per
ALTEX Edition
Publicat a
ALTEX - Alternatives to Animal Experimentation
Citació
Daneshian, M., L. M. Botana, M.-Y. Dechraoui Bottein, G. Buckland, M. Campàs, N. Dennison, R. W. Dickey, J. Diogène, et al. 2013 “A roadmap for hazard monitoring and risk assessment of marine biotoxins on the basis of chemical and biological test systems”. ALTEX - Alternatives to animal experimentation 30(4): 487–545. doi: 10.14573/altex.2013.4.487.
Programa
Aigües Marines i Continentals
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