Advances and gaps in SARS-CoV-2 infection models

Muñoz-Fontela, César; Widerspick, Lina; Albrecht, Randy A.; Beer, Martin; Carroll, Miles W.; de Wit, Emmie; Diamond, Diamond; Dowling, William E.; Funnell, Simon G. P.; García-Sastre, Adolfo; Gerhards, Nora M.; de Jong, Rineke; Munster, Vincent J.; Neyts, Johan; Perlman, Stanley; Reed, Douglas S.; Richt, Juergen A.; Riveros-Balta, Ximena; Roy, Chad J.; Salguero, Francisco J.; Schotsaert, Michael; Schwartz, Lauren M.; Seder, Robert A.; Segalés, Joaquim; Vasan, Seshadri S.; Henao-Restrepo, Ana María; Barouch, Dan H.

Abstract

AU The:global Pleaseco response nfirmthata tollhe Coronavirus adinglevelsa Disease rerepres 2019 entedcor (COVID-19) rectly: is now facing new challenges such as vaccine inequity and the emergence of SARS-CoV-2 variants of concern (VOCs). Preclinical models of disease, in particular animal models, are essential to investigate VOC pathogenesis, vaccine correlates of protection and postexposure therapies. Here, we provide an update from the World Health Organization (WHO) COVID-19 modeling expert group (WHO-COM) assembled by WHO, regarding advances in preclinical models. In particular, we discuss how animal model research is playing a key role to evaluate VOC virulence, transmission and immune escape, and how animal models are being refined to recapitulate COVID-19 demographic variables such as comorbidities and age.

Document Type

Article

Document version

Published version

Language

English

Subject (CDU)

619 - Veterinary science

Publisher

Public Library of Science

Is part of

PLoS Pathogens

Recommended citation

Muñoz-Fontela, César, Lina Widerspick, Randy A. Albrecht, Martin Beer, Miles W. Carroll, Emmie De Wit, Michael S. Diamond, et al. 2022.“Advances and Gaps in SARS-CoV-2 Infection Models.” PLOS Pathogens 18(1): e1010161. doi:10.1371/journal.ppat.1010161.

Program

Sanitat Animal

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ARTICLES CIENTÍFICS [3467]

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