Experimental Inoculation of Porcine Circovirus 3 (PCV-3) in Pregnant Gilts Causes PCV-3-Associated Lesions in Newborn Piglets that Persist until Weaning
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Author
Ruiz, Albert
Pérez, Mónica
Llorens, Anna
Huerta, Eva
Lohse, Robert
Balasch, Mònica
Publication date
2023-10-20ISSN
1865-1674
Abstract
Porcine circovirus 3 (PCV-3) has been detected in cases of reproductive failure but the pathogenesis of such infection is poorly
understood. So far, experimental PCV-3 inoculations have been performed only in piglets. Therefore, through the experimental
inoculation of pregnant gilts at two different time points (second and last third of gestation), this study aimed to evaluate the
outcome of PCV-3 infection in dams and their offspring until weaning age. Two weeks postinoculation, all gilts became viremic
and the infection lasted until the end of study. Farrowing occurred naturally, without evidence of reproductive disorders, and
piglets showed no significant clinical signs from farrowing to weaning (21 day-old). However, majority of the delivered piglets were
viremic, mostly until weaning age. Both newborn and weaned pigs showed different degrees of systemic, lymphohistiocytic arteritis
and periarteritis. Lesions were more severe in the piglets infected during the second third of gestation and worsened at weaning.
Additionally, PCV-3 detection in nervous and cardiac tissue and development of histopathological lesions in these tissues were
gestational dependent, as only occurred in piglets infected at second third of pregnancy. Piglets with lesions raised to weaning age
had less body weight than those without them. This study represents the first description of a PCV-3 experimental infection in
pregnant gilts, which resulted in transplacental infection, histological lesions in piglets mimicking those of natural occurring
disease, and lesser body weight in piglets with vascular lesions at weaning age. Obtained results allowed proposing a potential
pathogenesis model for PCV-3 infection in swine.
Document Type
Article
Document version
Published version
Language
English
Subject (CDU)
619 - Veterinary science
Pages
14
Publisher
Wiley
Is part of
Transboundary and Emerging Diseases
Citation
Cobos, Àlex, Albert Ruiz, Mónica Pérez, Anna Llorens, Eva Huerta, Florencia Correa‐Fiz, Robert Lohse, Mònica Balasch, Joaquim Segalés, and Marina Sibila. 2023. “Experimental inoculation of porcine circovirus 3 (PCV-3) in pregnant gilts causes PCV-3-Associated lesions in newborn piglets that persist until weaning”. Transboundary and Emerging Diseases 2023: 5270254. doi:10.1155/2023/5270254.
Program
Sanitat Animal
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- ARTICLES CIENTÍFICS [2555]
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