Metabolic insights and background from naturally affected pigs during Streptococcus suis outbreaks
Visualitza/Obre
Autor/a
Fabà, Lluís
Litjens, Ralph
Galofré-Milà, Núria
Segura, Mariela
Gottschalk, Marcelo
Doelman, John
Data de publicació
2023-11-06ISSN
2573-2102
Resum
Streptococcus suis (S. suis) is an endemic zoonotic pathogen still lacking adequate prevention in pigs. The present case study looked back to the
occurrence and consequences of S. suis outbreaks in our swine research facilities in search of new metabolic and physiological insight. From a
series of outbreaks, a dataset was created including 56 pigs sampled during disease detection based on clinical signs. Pigs suspected with S.
suis infection were defined as diseased (n = 28) and included pigs defined as neurologically diseased (n = 20) when severe neurological signs
(central nervous system dysfunctions, i.e., opisthotonos, ataxia, and generalized tremor) were observed. Another set of 28 pigs included respective pen mates from each case and were defined as control. Representative deaths were confirmed to be caused by S. suis.Tonsillar swabs
were collected and analyzed by quantitative polymerase chain reaction (qPCR) for total bacteria, total S. suis, and S. suis serotypes (SS) 2 (and/
or 1/2) and 9. Blood and sera were analyzed to quantify blood gases, minerals, and S. suis reactive immunoglobulins against current isolates.
Data collected included litter sibling associations, birth and weaning body weight (BW), and average daily gain (ADG) 7 d after the disease detection. In general, the disease increased pH, sO2 and the incidence of alkalosis, but reduced pCO2, glucose, Ca, P, Mg, K, and Na in blood/serum
compared to control. The SS2 (and/or SS1/2) prevalence was significantly (P < 0.05) increased in neurologically diseased pigs and its relative
abundance tended (P < 0.10) to increase in tonsils. In contrast, the relative abundance of total S. suis was lower (P > 0.05) in diseased pigs
than control pigs. Levels of S. suis reactive IgG2 were lower, but IgM were higher (P < 0.03) in neurologically affected pigs compared to control.
Furthermore, there was an increased proportion of sibling pigs that were diseased compared to control. In conclusion, our results evidence that
naturally affected pigs were associated to average performing pigs without any predisease trait to highlight but a sow/litter effect. Besides, neurologically affected pigs had increased S. suis (SS2 and/or 1/2) prevalence and relative abundance, a respiratory alkalosis profile, and mineral loss.
Tipus de document
Article
Versió del document
Versió publicada
Llengua
Anglès
Matèries (CDU)
619 - Veterinària
Pàgines
12
Publicat per
Oxford University Press
Publicat a
Translational Animal Science
Citació
Fabà, Lluís, Virginia Aragón, Ralph Litjens, Núria Galofré-Milà, Mariela Segura, Marcelo Gottschalk, and John Doelman. 2023. “Metabolic insights and background from naturally affected pigs during streptococcus SUIS outbreaks”. Translational animal science 7 (1): txad126. doi:10.1093/tas/txad126.
Programa
Sanitat Animal
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