A monoclonal antibody targeting a large surface of the receptor binding motif shows pan-neutralizing SARS-CoV-2 activity
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Autor/a
de Campos-Mata, Leire
Trinité, Benjamin
Modrego, Andrea
Tejedor Vaquero, Sonia
Pradenas, Edwards
Pons-Grífols, Anna
Rodrigo Melero, Natalia
Carlero, Diego
Marfil, Silvia
Santiago, César
Raïch-Regué, Dàlia
Bueno-Carrasco, María Teresa
Abancó, Ferran
Urrea, Victor
Izquierdo-Useros, Nuria
Riveira-Muñoz, Eva
Ballana, Ester
Vergara-Alert, Júlia
Carolis, Carlo
Arranz, Rocío
Blanco, Julià
Magri, Giuliana
Fecha de publicación
2024-02-05ISSN
2041-1723
Resumen
Here we report the characterization of 17T2, a SARS-CoV-2 pan-neutralizing
human monoclonal antibody isolated from a COVID-19 convalescent individual infected during the first pandemic wave. 17T2 is a class 1 VH1-58/κ3-20
antibody, derived from a receptor binding domain (RBD)-specific IgA+ memory
B cell, with a broad neutralizing activity against former and new SARS-CoV-2
variants, including XBB.1.16 and BA.2.86 Omicron subvariants. Consistently,
17T2 demonstrates in vivo prophylactic and therapeutic activity against Omicron BA.1.1 infection in K18-hACE2 mice. Cryo-electron microscopy reconstruction shows that 17T2 binds the BA.1 spike with the RBD in “up” position
and blocks the receptor binding motif, as other structurally similar antibodies
do, including S2E12. Yet, unlike S2E12, 17T2 retains its neutralizing activity
against all variants tested, probably due to a larger RBD contact area. These
results highlight the impact of small structural antibody changes on neutralizing performance and identify 17T2 as a potential candidate for future
clinical interventions.
Tipo de documento
Artículo
Versión del documento
Versión publicada
Lengua
Inglés
Materias (CDU)
619 - Veterinaria
Páginas
13
Publicado por
Nature Research
Publicado en
Nature Communications
Citación
De Campos-Mata, Leire, Benjamín Trinité, Andrea Modrego, Sonia Tejedor Vaquero, Edwards Pradenas, Anna Pons-Grífols, Natalia Rodrigo, et al. 2024. “A Monoclonal Antibody Targeting a Large Surface of the Receptor Binding Motif Shows Pan-neutralizing SARS-CoV-2 Activity.” Nature Communications. 15 (1): 1051. doi:10.1038/s41467-024-45171-9.
Program
Sanitat Animal
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