dc.contributor.author | Costa, Taiana | |
dc.contributor.author | Chaves, Aida J | |
dc.contributor.author | Valle, Rosa | |
dc.contributor.author | Darji, Ayub | |
dc.contributor.author | van Riel, Debby | |
dc.contributor.author | Kuiken, Thijs | |
dc.contributor.author | Majó, Natàlia | |
dc.contributor.author | Ramis, Antonio | |
dc.contributor.other | Producció Animal | ca |
dc.date.accessioned | 2024-04-04T12:18:05Z | |
dc.date.available | 2024-04-04T12:18:05Z | |
dc.date.issued | 2012-04-10 | |
dc.identifier.citation | Costa, Teresa, Andrea Chaves, Rosa Valle, Ayub Darji, Debby Van Riel, Thijs Kuiken, Natàlia Majó, and Antonio Ramis. 2012. “Distribution Patterns of Influenza Virus Receptors and Viral Attachment Patterns in the Respiratory and Intestinal Tracts of Seven Avian Species.” Veterinary Research 43 (1): 28. doi:10.1186/1297-9716-43-28. | ca |
dc.identifier.issn | 0928-4249 | ca |
dc.identifier.uri | http://hdl.handle.net/20.500.12327/2900 | |
dc.description.abstract | This study assessed the presence of sialic acid α-2,3 and α-2,6 linked glycan receptors in seven avian species. The
respiratory and intestinal tracts of the chicken, common quail, red-legged partridge, turkey, golden pheasant,
ostrich, and mallard were tested by means of lectin histochemistry, using the lectins Maackia amurensis agglutinin
II and Sambucus nigra agglutinin, which show affinity for α-2,3 and α-2,6 receptors, respectively. Additionally, the
pattern of virus attachment (PVA) was evaluated with virus histochemistry, using an avian-origin H4N5 virus and a
human-origin seasonal H1N1 virus. There was a great variation of receptor distribution among the tissues and
avian species studied. Both α-2,3 and α-2,6 receptors were present in the respiratory and intestinal tracts of the
chicken, common quail, red-legged partridge, turkey, and golden pheasant. In ostriches, the expression of the
receptor was basically restricted to α-2,3 in both the respiratory and intestinal tracts and in mallards the α-2,6
receptors were absent from the intestinal tract. The results obtained with the lectin histochemistry were, in general,
in agreement with the PVA. The differential expression and distribution of α-2,3 and α-2,6 receptors among various
avian species might reflect a potentially decisive factor in the emergence of new viral strains. | ca |
dc.description.sponsorship | This work was partially funded by the European Project SP5B-CT-2007- 044098 from the Sixth Framework Programme and by the project RTA 2011- 00111-C03. Aida JC Hernández is supported by the Programme Alban, the European Union Programme of High Level Scholarships for Latin America, scholarship #E07D400404CR. Human lung samples were kindly provided by Hospital Universitari Vall d’Hebrón (Barcelona, Spain) in accordance with protocols approved by the Ethics Committee on Clinic Investigations of the Hospital. | ca |
dc.format.extent | 13 | ca |
dc.language.iso | eng | ca |
dc.publisher | BMC | ca |
dc.relation.ispartof | Veterinary Research | ca |
dc.rights | Attribution 4.0 International | * |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | * |
dc.title | Distribution patterns of influenza virus receptors and viral attachment patterns in the respiratory and intestinal tracts of seven avian species | ca |
dc.type | info:eu-repo/semantics/article | ca |
dc.description.version | info:eu-repo/semantics/publishedVersion | ca |
dc.rights.accessLevel | info:eu-repo/semantics/openAccess | |
dc.embargo.terms | cap | ca |
dc.relation.projectID | EC/FP6/44098/EU/Molecular factors and mechanisms of transmission and pathogenicity of highly pathogenic Avian Influenza Virus/EUROFLU | ca |
dc.relation.projectID | MICINN/Programa Nacional de Proyectos de Investigación Fundamental/RTA2011-00111-C03-01/ES/Dinámica viral en diferentes especies aviares: mecanismos moleculares de transmisión y patogenicidad/ | ca |
dc.subject.udc | 619 | ca |
dc.identifier.doi | https://doi.org/10.1186/1297-9716-43-28 | ca |
dc.contributor.group | Sanitat Animal | ca |