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Unraveling the antiviral activity of plitidepsin against SARS-CoV-2 by subcellular and morphological analysis
(Elsevier, 2022-02-26)
The pandemic caused by the new coronavirus SARS-CoV-2 has made evident the need for broad-spectrum, efficient antiviral treatments to combat emerging and re-emerging viruses. Plitidepsin is an antitumor ...
Monkeypox (Mpox) requires continued surveillance, vaccines, therapeutics and mitigating strategies
(Elsevier, 2023-04-21)
The widespread outbreak of the monkeypox virus (MPXV) recognized in 2022 poses new challenges for public healthcare systems worldwide. With more than 86,000 people infected, there is concern that MPXV ...
Mycobacterium manresensis induces trained immunity in vitro
(Cell Press, 2023-05-13)
The COVID-19 pandemic posed a global health crisis, with new severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants weakening vaccine-driven protection. Trained immunity could help tackle ...
Feeding Spray-Dried Porcine Plasma to Pigs Improves the Protection Afforded by the African Swine Fever Virus (ASFV) BA71∆CD2 Vaccine Prototype against Experimental Challenge with the Pandemic ASFV—Study 2
(MDPI, 2023-04-10)
This study aimed to evaluate the effects of feeding spray-dried porcine plasma (SDPP) on the protection afforded by the BA71∆CD2 African swine fever virus (ASFV) vaccine prototype. Two groups of pigs ...
Enhanced antiviral immunity and dampened inflammation in llama lymph nodes upon MERS-CoV sensing: bridging innate and adaptive cellular immune responses in camelid reservoirs
(Frontiers Media, 2023-06-14)
Middle East respiratory syndrome coronavirus (MERS-CoV) infection can cause fatal pulmonary inflammatory disease in humans. Contrarily, camelids and bats are the main reservoir hosts, tolerant for ...
Pigs are not susceptible to SARS‐CoV‐2 infection but are a model for viral immunogenicity studies
(Wiley, 2020-10-02)
Conventional piglets were inoculated with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) through different routes, including intranasal, intratracheal, intramuscular and intravenous ones. ...
Increasing breast milk betaine modulates Akkermansia abundance in mammalian neonates and improves long-term metabolic health
(American Association for the Advancement of Science, 2021-03-31)
Accelerated postnatal growth is a potentially modifiable risk factor for future obesity. To study how specific breast milk components contribute to early growth and obesity risk, we quantified one-carbon ...
β-Cyclodextrins as affordable antivirals to treat coronavirus infection
(Elsevier, 2023-06-08)
The SARS-CoV-2 pandemic made evident that there are only a few drugs against coronavirus. Here we aimed to identify a cost-effective antiviral with broad spectrum activity and high safety profile. ...
Use of the informational spectrum methodology for rapid biological analysis of the novel coronavirus 2019-nCoV: prediction of potential receptor, natural reservoir, tropism and therapeutic/vaccine target [version 1; peer review: awaiting peer review]
(F1000Research, 2020-01-27)
A novel coronavirus recently identified in Wuhan, China (2019-nCoV) has
expanded the number of highly pathogenic coronaviruses affecting
humans. The 2019-nCoV represents a potential epidemic or ...
SARS-CoV-2 infection elicits a rapid neutralizing antibody response that correlates with disease severity
(Nature Research, 2021-01-28)
The protective effect of neutralizing antibodies in SARS-CoV-2 infected individuals is not yet well defined. To address this issue, we have analyzed the kinetics of neutralizing antibody responses and ...