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Recombinant PrPSc shares structural features with brain-derived PrPSc: Insights from limited proteolysis
(Public Library of Science, 2018-01-31)
Very solid evidence suggests that the core of full length PrPSc is a 4-rung β-solenoid, and that individual PrPSc subunits stack to form amyloid fibers. We recently used limited proteolysis to map the ...
African swine fever virus does not express viral microRNAs in experimentally infected pigs
(BioMed Central, 2018-09-03)
Background: African swine fever virus (ASFV) is the etiological agent of African swine fever (ASF), a re-expanding
devastating and highly lethal hemorrhagic viral disease. microRNAs (miRNAs) are a new ...
Experimental infection of dromedaries with Middle East respiratory syndrome-Coronavirus is accompanied by massive ciliary loss and depletion of the cell surface receptor dipeptidyl peptidase 4
(Nature Research, 2018-06-27)
Middle East respiratory syndrome (MERS) represents an important respiratory disease accompanied by lethal outcome in one-third of human patients. Recent data indicate that dromedaries represent an ...
Schmallenberg virus detection in Culicoides biting midges in Spain: First laboratory evidence for highly efficient infection of Culicoides of the Obsoletus complex and Culicoides imicola
(Wiley, 2017-05-04)
Since Schmallenberg disease was discovered in 2011, the disease rapidly spread across Europe. Culicoides biting midges have been implicated as putative Schmallenberg vectors in Europe. The detection of ...
Urban Wild Boars and Risk for Zoonotic Streptococcus suis, Spain
(Centers for Disease Control and Prevention, 2018-03-05)
Urban wild boars (Sus scrofa) from Barcelona, Spain, harbor great diversity of Streptococcus suis strains, including strains with the cps2 gene and with the same molecular profile as local human cases. ...
ICTV Virus Taxonomy Profile: Asfarviridae
(Microbiology Society, 2018-03-22)
The family Asfarviridae includes the single species African swine fever virus, isolates of which have linear dsDNA genomes of
170–194 kbp. Virions have an internal core, an internal lipid membrane, an ...
Chimeric camel/human heavy-chain antibodies protect against MERS-CoV infection
(American Association for the Advancement of Science, 2018-08-08)
Middle East respiratory syndrome coronavirus (MERS-CoV) continues to cause outbreaks in humans as a result of spillover events from dromedaries. In contrast to humans, MERS-CoV–exposed dromedaries develop ...
Porcine circovirus 3 is highly prevalent in serum and tissues and may persistently infect wild boar (Sus scrofa scrofa)
(Wiley, 2018-08-08)
Porcine circovirus 3 (PCV‐3) prevalence has been minimally investigated in wild boar; dynamics of infection and viral tissue distribution are currently unknown. In this study, serum samples from 518 ...
Assessment of the in vitro growing dynamics and kinetics of the non-pathogenic J and pathogenic 11 and 232 Mycoplasma hyopneumoniae strains
(BioMed Central, 2018-05-25)
Information on the in vitro growth of pathogenic and non-pathogenic Mycoplasma hyopneumoniae (M. hyopneumoniae) strains is scarce and controversial. Despite its limitations, the colour changing units ...