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A systems biology framework integrating GWAS and RNA-seq to shed light on the molecular basis of sperm quality in swine
(BMC, 2020-12-08)
Background
Genetic pressure in animal breeding is sparking the interest of breeders for selecting elite boars with higher sperm quality to optimize ejaculate doses and fertility rates. However, the ...
Analysis of porcine adipose tissue transcriptome reveals differences in de novo fatty acid synthesis in pigs with divergent muscle fatty acid composition
(BMC, 2013-12-01)
Background: In pigs, adipose tissue is one of the principal organs involved in the regulation of lipid metabolism.
It is particularly involved in the overall fatty acid synthesis with consequences in ...
Identification of candidate regulatory genes for intramuscular fatty acid composition in pigs by transcriptome analysis
(BMC, 2024-02-12)
Background
Intramuscular fat (IMF) content and its fatty acid (FA) composition are typically controlled by several genes, each with a small effect. In the current study, to pinpoint candidate genes and ...
About the existence of common determinants of gene expression in the porcine liver and skeletal muscle
(BMC, 2019-06-24)
Background: The comparison of expression QTL (eQTL) maps obtained in different tissues is an essential step to
understand how gene expression is genetically regulated in a context-dependent manner. In ...
Integration of liver gene co-expression networks and eGWAs analyses highlighted candidate regulators implicated in lipid metabolism in pigs
(Nature Research, 2017-04-19)
In the present study, liver co-expression networks and expression Genome Wide Association Study
(eGWAS) were performed to identify DNA variants and molecular pathways implicated in the functional
regulatory ...
Global analysis of the association between pig muscle fatty acid composition and gene expression using RNA-Seq
(Nature Research, 2023-01-11)
Fatty acids (FAs) play an essential role as mediators of cell signaling and signal transduction, affecting metabolic homeostasis and determining meat quality in pigs. However, FAs are transformed by the ...
Genome-wide linkage analysis of QTL for growth and body composition employing the PorcineSNP60 BeadChip
(BMC, 2012-05-20)
Background: The traditional strategy to map QTL is to use linkage analysis employing a limited number of markers.
These analyses report wide QTL confidence intervals, making very difficult to identify ...
Liver transcriptome profile in pigs with extreme phenotypes of intramuscular fatty acid composition
(BMC, 2012-10-11)
Background: New advances in high-throughput technologies have allowed for the massive analysis of genomic
data, providing new opportunities for the characterization of the transcriptome architectures. ...