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Removal of the Erns RNase Activity and of the 39 Untranslated Region Polyuridine Insertion in a Low-Virulence Classical Swine Fever Virus Triggers a Cytokine Storm and Lethal Disease
(American Society for Microbiology, 2022-06-27)
In this study, we assessed the potential synergistic effect of the Erns RNase activity and the poly-U insertion in the 3′ untranslated region (UTR) of the low-virulence classical swine fever virus (CSFV) ...
Investigation of chronic and persistent classical swine fever infections under field conditions and their impact on vaccine efficacy
(BMC, 2019-07-15)
Background: Recent studies have hypothesized that circulation of classical swine fever virus (CSFV) variants when the immunity induced by the vaccine is not sterilizing might favour viral persistence. ...
A Polyuridine Insertion in the 3′ Untranslated Region of Classical Swine Fever Virus Activates Immunity and Reduces Viral Virulence in Piglets
(American Society for Microbiology, 2020-01-06)
Low-virulence classical swine fever virus (CSFV) strains make CSF eradication particularly difficult. Few data are available on the molecular determinants of CSFV virulence. The aim of the present study ...
Abrogation of the RNase activity of Erns in a low virulence classical swine fever virus enhances the humoral immune response and reduces virulence, transmissibility, and persistence in pigs
(Taylor & Francis Open Access, 2021-08-02)
The prevalence of low virulence classical swine fever virus (CSFV) strains makes viral eradication difficult in endemic countries. However, the determinants for natural CSFV attenuation and persistence ...
Evolutionary-Related High- and Low-Virulent Classical Swine Fever Virus Isolates Reveal Viral Determinants of Virulence
(MDPI, 2024-01-19)
Classical swine fever (CSF) has been eradicated from Western and Central Europe but
remains endemic in parts of Central and South America, Asia, and the Caribbean. CSF virus
(CSFV) has been endemic ...
Identification of an Immunosuppressive Cell Population during Classical Swine Fever Virus Infection and Its Role in Viral Persistence in the Host
(MDPI, 2019-09-04)
Classical swine fever virus (CSFV) remains a highly important pathogen, causing major
losses in the swine industry. Persistent infection is highly relevant for CSFV maintenance in the field;
however, ...
Foetal Immune Response Activation and High Replication Rate during Generation of Classical Swine Fever Congenital Infection
(MDPI, 2020-04-14)
Classical swine fever virus (CSFV) induces trans-placental transmission and congenital viral persistence; however, the available information is not updated. Three groups of sows were infected at ...
Postnatal Persistent Infection with Classical Swine Fever Virus and Its Immunological Implications
(Public Library of Science, 2015-05-04)
It is well established that trans-placental transmission of classical swine fever virus (CSFV) during mid-gestation can lead to persistently infected offspring. The aim of the present study was to ...
Efficacy of a live attenuated vaccine in classical swine fever virus postnatally persistently infected pigs
(BMC, 2015-07-09)
Classical swine fever (CSF) causes major losses in pig farming, with various degrees of disease severity. Efficient live attenuated vaccines against classical swine fever virus (CSFV) are used routinely ...