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Bacterial inclusion bodies are industrially exploitable amyloids
(Oxford University Press, 2018-10-24)
Understanding the structure, functionalities and biology of functional amyloids is an issue of emerging interest. Inclusion bodies, namely protein clusters formed in recombinant bacteria during protein ...
CXCR4+-targeted protein nanoparticles produced in the food-grade bacterium Lactococcus lactis
(Future Science Group, 2016-08-16)
Aim: Lactococcus lactis is a Gram-positive (endotoxin-free) food-grade bacteria exploited as alternative to Escherichia coli for recombinant protein production. We have explored here for the first time ...
Functional inclusion bodies produced in the yeast Pichia pastoris
(BMC, 2016-10-01)
Background: Bacterial inclusion bodies (IBs) are non‑toxic protein aggregates commonly produced in recombinant bacteria. They are formed by a mixture of highly stable amyloid‑like fibrils and releasable ...
Complex Particulate Biomaterials as Immunostimulant-Delivery Platforms
(Public Library of Science, 2016-10-07)
The control of infectious diseases is a major current challenge in intensive aquaculture. Most commercial vaccines are based on live attenuated or inactivated pathogens that are usually combined with ...
The biological potential hidden in inclusion bodies
(MDPI, 2020-02-15)
Inclusion bodies (IBs) are protein nanoclusters obtained during recombinant protein production processes, and several studies have demonstrated their potential as biomaterials for therapeutic protein ...
The Potential of Metalloproteinase-9 Administration to Accelerate Mammary Involution and Boost the Immune System at Dry-Off
(MDPI, 2021-11-30)
The dry period is decisive for the milking performance of dairy cows. The promptness of
mammary gland involution at dry-off affects not only the productivity in the next lactation, but also
the risk ...
Recombinant protein-based nanoparticles: Elucidating their inflammatory effects in vivo and their potential as a new therapeutic format
(MDPI, 2020-05-13)
Bacterial inclusion bodies (IBs) are protein-based nanoparticles of a few hundred nanometers formed during recombinant protein production processes in different bacterial hosts. IBs contain active protein ...
In Vivo Bactericidal Efficacy of GWH1 Antimicrobial Peptide Displayed on Protein Nanoparticles, a Potential Alternative to Antibiotics
(MDPI, 2020-12-17)
Oligomerization of antimicrobial peptides into nanosized supramolecular complexes produced in biological systems (inclusion bodies and self-assembling nanoparticles) seems an appealing alternative to ...
Selecting Subpopulations of High-Quality Protein Conformers among Conformational Mixtures of Recombinant Bovine MMP-9 Solubilized from Inclusion Bodies
(MDPI, 2021-03-16)
A detailed workflow to analyze the physicochemical characteristics of mammalian matrix metalloproteinase (MMP-9) protein species obtained from protein aggregates (inclusion bodies—IBs) was followed. ...
Aggregation-prone peptides modulate activity of bovine interferon gamma released from naturally occurring protein nanoparticles
(Elsevier, 2020-02-03)
Efficient protocols for the production of recombinant proteins are indispensable for the development of the biopharmaceutical sector. Accumulation of recombinant proteins in naturally-occurring protein ...