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The emergence of classical BSE from atypical/Nor98 scrapie
(National Academy of Sciences, 2019-12-16)
Atypical/Nor98 scrapie (AS) is a prion disease of small ruminants. Currently there are no efficient measures to control this form of prion disease, and, importantly, the zoonotic potential and the risk ...
Classical BSE prions emerge from asymptomatic pigs challenged with atypical/Nor98 scrapie
(Nature Research, 2021-08-31)
Pigs are susceptible to infection with the classical bovine spongiform encephalopathy (C-BSE) agent following experimental inoculation, and PrPSc accumulation was detected in porcine tissues after the ...
Mixtures of prion substrains in natural scrapie cases revealed by ovinised murine models
(Nature Research, 2020-03-19)
Phenotypic variability in prion diseases, such as scrapie, is associated to the existence of prion strains, which are different pathogenic prion protein (PrPSc) conformations with distinct pathobiological ...