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    • Recombinant PrPSc shares structural features with brain-derived PrPSc: Insights from limited proteolysis 

      Sevillano, Alejandro M.; Fernández-Borges, Natalia; Younas, Neelam; Wang, Fei; Elezgarai, Saioa R.; Bravo, Susana; Vázquez-Fernández, Ester; Rosa, Isaac; Eraña, Hasier; Gil, David; Veiga, Sonia; Vidal, Enric; Erickson-Beltran, Melissa L.; Requena, Jesús R.
      Very solid evidence suggests that the core of full length PrPSc is a 4-rung β-solenoid, and that individual PrPSc subunits stack to form amyloid fibers. We recently used limited proteolysis to map the β-strands and connecting ...