Browsing ARTICLES CIENTÍFICS by Author "Wang, Miaomiao"
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A Novel E2 Glycoprotein Subunit Marker Vaccine Produced in Plant Is Able to Prevent Classical Swine Fever Virus Vertical Transmission after Double Vaccination
Park, Youngmin; Oh, Yeonsu; Wang, Miaomiao; Ganges, Llilianne; Bohórquez, José Alejandro; Park, Soohong; Gu, Sungmin; Park, Jungae; Lee, Sangmin; Kim, Jongkook; Sohn, Eun-Ju (Vaccines, 2021-04-22) Sanitat AnimalThe efficacy of a novel subunit vaccine candidate, based in the CSFV E2 glycoprotein produced in plants to prevent classical swine fever virus (CSFV) vertical transmission, was evaluated. A Nicotiana ... -
A Polyuridine Insertion in the 3′ Untranslated Region of Classical Swine Fever Virus Activates Immunity and Reduces Viral Virulence in Piglets
Wang, Miaomiao; Liniger, Matthias; Muñoz-González, Sara; Bohórquez, José Alejandro; Hinojosa, Yoandry; Gerber, Markus; López-Soria, Sergio; Rosell, Rosa; Ruggli, Nicolas; Ganges, Llilianne (Journal of Virology, 2020-01-06) Sanitat AnimalLow-virulence classical swine fever virus (CSFV) strains make CSF eradication particularly difficult. Few data are available on the molecular determinants of CSFV virulence. The aim of the present study ... -
Abrogation of the RNase activity of Erns in a low virulence classical swine fever virus enhances the humoral immune response and reduces virulence, transmissibility, and persistence in pigs
Wang, Miaomiao; Bohórquez, José Alejandro; Hinojosa, Yoandry; Muñoz-González, Sara; Gerber, Markus; Coronado, Liani; Perera, Carmen Laura; Liniger, Matthias; Ruggli, Nicolas; Ganges, Llilianne (Virulence, 2021-08-02) Sanitat AnimalThe prevalence of low virulence classical swine fever virus (CSFV) strains makes viral eradication difficult in endemic countries. However, the determinants for natural CSFV attenuation and persistence ... -
Decrypting the Origin and Pathogenesis in Pregnant Ewes of a New Ovine Pestivirus Closely Related to Classical Swine Fever Virus
Wang, Miaomiao; Sozzi, Enrica; Bohórquez, José Alejandro; Alberch, Mònica; Pujols, Joan; Cantero, Guillermo; Gaffuri, Alessandra; Lelli, Davide; Rosell, Rosa; Bensaid, Albert; Domingo, Mariano; Pérez, Lester Josue; Moreno, Ana; Ganges, Llilianne (Viruses, 2020-07-17) Sanitat AnimalThis study shows the origin and the pathogenic role of a novel ovine pestivirus (OVPV) isolated in 2017 in Italy, as a pathogenic agent causing severe abortions after infection in pregnant ewes and high ... -
Early and Solid Protection Afforded by the Thiverval Vaccine Provides Novel Vaccination Alternatives Against Classical Swine Fever Virus
Lamothe-Reyes, Yaneysis; Bohórquez, José Alejandro; Wang, Miaomiao; Alberch, Mònica; Pérez-Simó, Marta; Ganges, Llilianne; Rosell, Rosa; Ganges, Llilianne (Vaccines, 2021-05-06) Sanitat AnimalClassical swine fever virus (CSFV) remains a challenge for the porcine industry. Inefficient vaccination programs in some endemic areas may have contributed to the emergence of low and moderate virulence ... -
Low CD4/CD8 ratio in classical swine fever postnatalpersistent infection generated at 3 weeks after birth
Bohórquez, José Alejandro; Wang, Miaomiao; Pérez‐Simó, Marta; Vidal, Enric; Rosell, Rosa; Ganges, Llilianne (Transboundary and Emerging Diseases, 2018-11-20) Sanitat AnimalClassical swine fever virus (CSFV) is one of the most important pathogens affectingswine. After infection with a moderate virulence strain at 8 hours after birth, CSFV isable to induce viral persistence. ... -
Removal of the Erns RNase Activity and of the 39 Untranslated Region Polyuridine Insertion in a Low-Virulence Classical Swine Fever Virus Triggers a Cytokine Storm and Lethal Disease
Wang, Miaomiao; Bohórquez, José Alejandro; Muñoz-González, Sara; Gerber, Markus; Alberch, Mònica; Pérez-Simó, Marta; Abad, Xavier; Liniger, Matthias; Ruggli, Nicolas; Ganges, Llilianne (Journal of Virology, 2022-06-27) Sanitat AnimalIn this study, we assessed the potential synergistic effect of the Erns RNase activity and the poly-U insertion in the 3′ untranslated region (UTR) of the low-virulence classical swine fever virus (CSFV) ... -
The FlagT4G Vaccine Confers a Strong and Regulated Immunity and Early Virological Protection against Classical Swine Fever
Bohorquez Garzon, Jose Alejandro; Wang, Miaomiao; Díaz, Ivan; Alberch, Mònica; Pérez-Simó, Marta; Rosell, Rosa; Gladue, Douglas P.; Borca, Manuel V.; Ganges, Llilianne (Viruses, 2022-09-02) Sanitat AnimalControl of classical swine fever virus (CSFV) in endemic countries relies on vaccination, mostly using vaccines that do not allow for differentiation of vaccinated from infected animals (DIVA). FlagT4G ... -
The new emerging ovine pestivirus can infect pigs and confers strong protection against classical swine fever virus
Bohórquez, José Alejandro; Sozzi, Enrica; Wang, Miaomiao; Alberch, Mònica; Abad, Xavier; Gaffuri, Alessandra; Lelli, Davide; Rosell, Rosa; Pérez, Lester Josue; Moreno, Ana; Ganges, Llilianne (Transboundary and Emerging Diseases, 2021-04-25) Sanitat AnimalSeveral emerging pestiviruses have been reported lately, some of which have proved to cause disease. Recently, a new ovine pestivirus (OVPV), isolated from aborted lambs, with high genetic identity to ... -
Vaccination against swine influenza in pigs causes different drift evolutionary patterns upon swine influenza virus experimental infection and reduces the likelihood of genomic reassortments
López Valiñas, Álvaro; Valle, Marta; Wang, Miaomiao; Darji, Ayub; Cantero, Guillermo; Chiapponi, Chiara; Segalés, Joaquim; Ganges, Llilianne; Núñez, J Ignacio (Frontiers in Cellular and Infection Microbiology, 2023-03-13) Sanitat AnimalInfluenza A viruses (IAVs) can infect a wide variety of bird and mammal species. Their genome is characterized by 8 RNA single stranded segments. The low proofreading activity of their polymerases and ...