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Sequence edition of single domains modulates the final immune and antimicrobial potential of a new generation of multidomain recombinant proteins
(Nature Research, 2021-12-10)
Combining several innate immune peptides into a single recombinant antimicrobial and immunomodulatory polypeptide has been recently demonstrated. However, the versatility of the multidomain design, the ...
A new generation of recombinant polypeptides combines multiple protein domains for effective antimicrobial activity
(BMC, 2020-06-05)
Background
Although most of antimicrobial peptides (AMPs), being relatively short, are produced by chemical synthesis, several AMPs have been produced using recombinant technology. However, AMPs could ...
Exploring the impact of the recombinant Escherichia coli strain on defensins antimicrobial activity: BL21 versus Origami strain
(BMC, 2022-05-09)
The growing emergence of microorganisms resistant to antibiotics has prompted the development of alternative antimicrobial therapies. Among them, the antimicrobial peptides produced by innate immunity, ...
Quality comparison of recombinant soluble proteins and proteins solubilized from bacterial inclusion bodies
(Elsevier, 2022-09-20)
Recombinant protein production in bacteria is often accompanied by the formation of aggregates, known as inclusion bodies (IBs). Although several strategies have been developed to minimize protein ...
Lactiplantibacillus plantarum: a new example of inclusion body producing bacteria
(BMC, 2023-06-09)
Background
Lactic Acid Bacteria such as Lactococcus lactis, Latilactobacillus sakei (basonym: Lactobacillus sakei) and Lactiplantibacillus plantarum (basonym: Lactobacillus plantarum) have gained ...
Potential of Oral Nanoparticles Containing Cytokines as Intestinal Mucosal Immunostimulants in Pigs: A Pilot Study
(MDPI, 2022-04-21)
Antimicrobial resistance is a global threat that is worryingly rising in the livestock sector.
Among the proposed strategies, immunostimulant development appears an interesting approach to
increase ...
A Novel Generation of Tailored Antimicrobial Drugs Based on Recombinant Multidomain Proteins
(MDPI, 2023-03-26)
Antibiotic resistance has exponentially increased during the last years. It is necessary to develop new antimicrobial drugs to prevent and treat infectious diseases caused by multidrug- or extensively-drug ...