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dc.contributor.authorChauvigné, François
dc.contributor.authorYilmaz, Ozlem
dc.contributor.authorFerré, Alba
dc.contributor.authorFjelldal, Per Gunnar
dc.contributor.authorFinn, Roderick Nigel
dc.contributor.authorCerdà, Joan
dc.contributor.otherProducció Animalca
dc.date.accessioned2019-12-17T16:21:44Z
dc.date.available2019-12-17T16:21:44Z
dc.date.issued2019-12-11
dc.identifier.citationChauvigné, François, Ozlem Yilmaz, Alba Ferré, Per Gunnar Fjelldal, Roderick Nigel Finn, and Joan Cerdà. 2019. "The Vertebrate Aqp14 Water Channel Is A Neuropeptide-Regulated Polytransporter". Communications Biology 2 (1): 1-13. https://doi.org/10.1038/s42003-019-0713-yca
dc.identifier.issn2399-3642ca
dc.identifier.urihttp://hdl.handle.net/20.500.12327/596
dc.description.abstractWater channels (aquaporins) were originally discovered in mammals with fourteen subfamilies now identified (AQP0-13). Here we show that a functional Aqp14 subfamily phylogenetically related to AQP4-type channels exists in all vertebrate lineages except hagfishes and eutherian mammals. In contrast to the water-selective classical aquaporins, which have four aromatic-arginine constriction residues, Aqp14 proteins present five non-aromatic constriction residues and facilitate the permeation of water, urea, ammonia, H2O2 and glycerol. Immunocytochemical assays suggest that Aqp14 channels play important osmoregulatory roles in piscine seawater adaptation. Our data indicate that Aqp14 intracellular trafficking is tightly regulated by the vasotocinergic/isotocinergic neuropeptide and receptor systems, whereby protein kinase C and A transduction pathways phosphorylate highly conserved C-terminal residues to control channel plasma membrane insertion. The neuropeptide regulation of Aqp14 channels thus predates the vasotocin/vasopressin regulation of AQP2-5-6 orthologs observed in tetrapods. These findings demonstrate that vertebrate Aqp14 channels represent an ancient subfamily of neuropeptide-regulated polytransporters.ca
dc.format.extent13ca
dc.language.isoengca
dc.publisherSpringer Natureca
dc.relation.ispartofCommunications Biologyca
dc.rightsAttribution 4.0 Internationalca
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
dc.titleThe vertebrate Aqp14 water channel is a neuropeptide-regulated polytransporterca
dc.typeinfo:eu-repo/semantics/articleca
dc.description.versioninfo:eu-repo/semantics/publishedVersionca
dc.rights.accessLevelinfo:eu-repo/semantics/openAccess
dc.embargo.termscapca
dc.relation.projectIDMINECO/Programa Estatal de I+D+I orientada a los retos de la sociedad/AGL2016-76802-R/ES/Canales de agua e ionicos como nuevos marcadores de estrés oxidativo y cinemáticos de la calidad del esperma en teleosteos marinos/SPERMIOPORINca
dc.relation.projectIDMINECO/Programa Estatal de promoción del talento y su empleabilidad en I+D+I/RYC-2015-17103/ES/ /ca
dc.subject.udc639ca
dc.identifier.doihttps://doi.org/10.1038/s42003-019-0713-yca
dc.contributor.groupAqüiculturaca


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