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dc.contributor.authorAureli, Raffaella
dc.contributor.authorLa-Marta, James
dc.contributor.authorGrossi, Alberto Blak
dc.contributor.authorDella Pia, Eduardo Antonio
dc.contributor.authorEsteve-Garcia, Enric
dc.contributor.authorWulf-Andersen, Linda
dc.contributor.authorThorsen, Michael
dc.contributor.otherProducció Animalca
dc.date.accessioned2018-11-06T18:16:44Z
dc.date.available2018-11-06T18:16:44Z
dc.date.issued2018-09-25
dc.identifier.citationRaffaella Aureli, James La-Marta, Alberto Blak Grossi, Eduardo Antonio Della Pia, Enric Esteve-Garcia, Linda Wulf-Andersen, Michael Thorsen, A novel glucuronoxylan hydrolase produced by fermentation is safe as feed additive: toxicology and tolerance in broiler chickens, Regulatory Toxicology and Pharmacology, Volume 99, 2018, Pages 213-224,ca
dc.identifier.issn0273-2300ca
dc.identifier.urihttp://hdl.handle.net/20.500.12327/60
dc.description.abstractThe current study presents a safety evaluation of a novel glucuronoxylan hydrolase (EC 3.2.1.136) from Bacillus subtilis produced in Bacillus licheniformis. The glucuronoxylan hydrolase preparation did not exhibit irritative potential to the eye and skin when applied in in vitro models. The glucuronoxylan hydrolase preparation was non-mutagenic and non-clastogenic in in vitro tests. Oral administration of the glucuronoxylan hydrolase preparation to rats did not cause any adverse effect in a 90-days subchronic toxicity study. A tolerance study was performed with broiler chickens and confirmed that this glucuronoxylan hydrolase is safe for broiler chickens when fed at the maximum recommended dose, as well as at the 10 times higher dose. In conclusion, there are no safety concerns with using this novel glucuronoxylan hydrolase as a feed additive as it is toxicologically inert and the glucuronoxylan hydrolase is well tolerated by broiler chickens. The beneficial safety evaluation of glucuronoxylan hydrolase is consistent with the fact that this type of enzyme is ubiquitous in nature.ca
dc.format.extent12ca
dc.language.isoengca
dc.publisherElsevierca
dc.relation.ispartofRegulatory Toxicology and Pharmacologyca
dc.rightsAttribution 4.0 International*
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
dc.titleA novel glucuronoxylan hydrolase produced by fermentation is safe as feed additive: toxicology and tolerance in broiler chickensca
dc.typeinfo:eu-repo/semantics/articleca
dc.description.versionreprintca
dc.embargo.termscapca
dc.subject.udc636 - Explotació i cria d'animals. Cria del bestiar i d'animals domèsticsca
dc.identifier.doihttps://doi.org/10.1016/j.yrtph.2018.09.024ca
dc.contributor.groupNutrició Animalca


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Attribution 4.0 International
Except where otherwise noted, this item's license is described as http://creativecommons.org/licenses/by/4.0/