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dc.contributor.authorMoreno, Leandro F.
dc.contributor.authorAhmed, Abdalla A. O.
dc.contributor.authorBrankovics, Balázs
dc.contributor.authorCuomo, Christina A.
dc.contributor.authorMenken, Steph B. J.
dc.contributor.authorTaj-Aldeen, Saad J.
dc.contributor.authorFaidah, Hani
dc.contributor.authorStielow, J. Benjamin
dc.contributor.authorTeixeira, Marcus de M.
dc.contributor.authorPrenafeta-Boldú, Francesc X.
dc.contributor.authorVicente, Vania A.
dc.contributor.authorde Hoog, Sybren
dc.contributor.otherProducció Animalca
dc.date.accessioned2018-11-07T10:04:29Z
dc.date.available2018-11-07T10:04:29Z
dc.date.issued2018-01-11
dc.identifier.citationMoreno, L., Ahmed, A., Brankovics, B., Cuomo, C., Menken, S., & Taj-Aldeen, S. et al. (2018). Genomic Understanding of an Infectious Brain Disease from the Desert. G3&Amp;#58; Genes|Genomes|Genetics, g3.300421.2017. doi:10.1534/g3.117.300421ca
dc.identifier.issn2160-1836ca
dc.identifier.urihttp://hdl.handle.net/20.500.12327/61
dc.description.abstractRhinocladiella mackenziei accounts for the majority of fungal brain infections in the Middle East, and is restricted to the arid climate zone between Saudi Arabia and Pakistan. Neurotropic dissemination caused by this fungus has been reported in immunocompromised, but also immunocompetent individuals. If untreated, the infection is fatal. Outside of humans, the environmental niche of R. mackenziei is unknown, and the fungus has been only cultured from brain biopsies. In this paper, we describe the whole-genome resequencing of two R. mackenziei strains from patients in Saudi Arabia and Qatar. We assessed intraspecies variation and genetic signatures to uncover the genomic basis of the pathogenesis, and potential niche adaptations. We found that the duplicated genes (paralogs) are more susceptible to accumulating significant mutations. Comparative genomics with other filamentous ascomycetes revealed a diverse arsenal of genes likely engaged in pathogenicity, such as the degradation of aromatic compounds and iron acquisition. In addition, intracellular accumulation of trehalose and choline suggests possible adaptations to the conditions of an arid climate region. Specifically, protein family contractions were found, including short-chain dehydrogenase/reductase SDR, the cytochrome P450 (CYP) (E-class), and the G-protein b WD-40 repeat. Gene composition and metabolic potential indicate extremotolerance and hydrocarbon assimilation, suggesting a possible environmental habitat of oil-polluted desert soilca
dc.format.extent14ca
dc.language.isoengca
dc.publisherGenetics Society of Americaca
dc.relation.ispartofG3: Genes, Genomes, Geneticsca
dc.rightsAttribution 4.0 International*
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
dc.titleGenomic Understanding of an Infectious Brain Disease from the Desertca
dc.typeinfo:eu-repo/semantics/articleca
dc.description.versioninfo:eu-repo/semantics/publishedVersionca
dc.rights.accessLevelinfo:eu-repo/semantics/openAccess
dc.embargo.termscapca
dc.subject.udc616.8 - Neurologia. Neuropatologia. Sistema nerviósca
dc.identifier.doihttps://doi.org/10.1534/g3.117.300421ca
dc.contributor.groupSostenibilitat en Biosistemesca


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Attribution 4.0 International
Except where otherwise noted, this item's license is described as http://creativecommons.org/licenses/by/4.0/
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