Blocking transmission of Middle East respiratory syndrome coronavirus (MERS-CoV) in llamas by vaccination with a recombinant spike protein
Visualitza/Obre
Autor/a
Rodon, Jordi
Okba, Nisreen M. A.
Te, Nigeer
van Dieren, Brenda
Bosch, Berend-Jan
Haagmans, Bart L.
Vergara-Alert, Júlia
Data de publicació
2019-11-12ISSN
2222-1751
Resum
The ongoing Middle East respiratory syndrome coronavirus (MERS-CoV) outbreaks pose a worldwide public health threat. Blocking MERS-CoV zoonotic transmission from dromedary camels, the animal reservoir, could potentially reduce the number of primary human cases. Here we report MERS-CoV transmission from experimentally infected llamas to naïve animals. Directly inoculated llamas shed virus for at least 6 days and could infect all in-contact naïve animals 4-5 days after exposure. With the aim to block virus transmission, we examined the efficacy of a recombinant spike S1-protein vaccine. In contrast to naïve animals, in-contact vaccinated llamas did not shed infectious virus upon exposure to directly inoculated llamas, consistent with the induction of strong virus neutralizing antibody responses. Our data provide further evidence that vaccination of the reservoir host may impede MERS-CoV zoonotic transmission to humans.
Tipus de document
Article
Versió del document
Versió publicada
Llengua
English
Matèries (CDU)
619 - Veterinària
Pàgines
12
Publicat per
Taylor & Francis Open
Publicat a
Emerging Microbes and Infections
Citació
Rodon, Jordi, Nisreen M. A. Okba, Nigeer Te, Brenda van Dieren, Berend-Jan Bosch, Albert Bensaid, Joaquim Segalés, Bart L. Haagmans, and Júlia Vergara-Alert. 2019. "Blocking Transmission Of Middle East Respiratory Syndrome Coronavirus (MERS-Cov) In Llamas By Vaccination With A Recombinant Spike Protein". Emerging Microbes & Infections 8 (1): 1593-1603. Informa UK Limited. doi:10.1080/22221751.2019.1685912.
Número de l'acord de la subvenció
EC/PF7/115760/EU/Zoonotic Anticipation and Preparedness Initiative/ZAPI
EC/H2020/731014/EU/Veterinary Biocontained facility Network for excellence in animal infectiology research and experimentation /VetBioNet
Programa
Sanitat Animal
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