dc.contributor.author | Guirado, Pedro | |
dc.contributor.author | Paytubi, Sonia | |
dc.contributor.author | Miró, Elisenda | |
dc.contributor.author | Iglesias-Torrens, Yaidelis | |
dc.contributor.author | Navarro, Ferran | |
dc.contributor.author | Cerdà-Cuéllar, Marta | |
dc.contributor.author | Attolini, Camille Stephan-Otto | |
dc.contributor.author | Balsalobre, Carlos | |
dc.contributor.author | Madrid, Cristina | |
dc.contributor.other | Producció Animal | ca |
dc.date.accessioned | 2020-04-20T10:11:38Z | |
dc.date.available | 2020-04-20T10:11:38Z | |
dc.date.issued | 2020-02-26 | |
dc.identifier.citation | Guirado, Pedro, Sonia Paytubi, Elisenda Miró, Yaidelis Iglesias-Torrens, Ferran Navarro, Marta Cerdà-Cuéllar, Camille Stephan-Otto Attolini, Carlos Balsalobre, and Cristina Madrid. 2020. "Differential Distribution Of The Wlan And Cgtb Genes, Associated With Guillain-Barré Syndrome, In Campylobacter Jejuni Isolates From Humans, Broiler Chickens, And Wild Birds". Microorganisms 8 (3): 325. MDPI AG. doi:10.3390/microorganisms8030325. | ca |
dc.identifier.issn | 2076-2607 | ca |
dc.identifier.uri | http://hdl.handle.net/20.500.12327/703 | |
dc.description.abstract | Campylobacter jejuni causes campylobacteriosis, a bacterial gastroenteritis with high
incidence worldwide. Moreover, C. jejuni infection can trigger the polyneuropathic disorder
denominated Guillain-Barré syndrome (GBS). The C. jejuni strains that can elicit GBS carry either
wlaN or cgtB, coding both genes for a β-1,3-galactosyltransferase enzyme that is required for the
production of sialylated lipooligosaccharide (LOSSIAL). We described a differential prevalence of the
genes wlaN and cgtB in C. jejuni isolates from three different ecological niches: humans, broiler
chickens, and wild birds. The distribution of both genes, which is similar between broiler chicken
and human isolates and distinct when compared to the wild bird isolates, suggests a host-dependent
distribution. Moreover, the prevalence of the wlaN and cgtB genes seems to be restricted to some
clonal complexes. Gene sequencing identified the presence of new variants of the G- homopolymeric
tract within the wlaN gene. Furthermore, we detected two variants of a G rich region within the cgtB
gene, suggesting that, similarly to wlaN, the G-tract in the cgtB gene mediates the phase variation
control of cgtB expression. Caco-2 cell invasion assays indicate that there is no evident correlation
between the production of LOSSIAL and the ability to invade eukaryotic cells. | ca |
dc.format.extent | 12 | ca |
dc.language.iso | eng | ca |
dc.publisher | MDPI | ca |
dc.relation.ispartof | Microorganisms | ca |
dc.rights | Attribution 4.0 International | ca |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | * |
dc.title | Differential distribution of the wlaN and cgtB genes, Associated with Guillain-Barré Syndrome, in Campylobacter jejuni isolates from humans, broiler chickens, and wild birds | ca |
dc.type | info:eu-repo/semantics/article | ca |
dc.description.version | info:eu-repo/semantics/publishedVersion | ca |
dc.rights.accessLevel | info:eu-repo/semantics/openAccess | |
dc.embargo.terms | cap | ca |
dc.relation.projectID | MINECO/Programa Estatal de I+D+I orientada a los retos de la sociedad/AGL2013-45339R/ES/Identificación de factores implicados en la transmisión de la campilobacteriosis por alimentos/ | ca |
dc.subject.udc | 619 | ca |
dc.identifier.doi | https://doi.org/10.3390/microorganisms8030325 | ca |
dc.contributor.group | Sanitat Animal | ca |