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dc.contributor.authorVidaña, Beatriz
dc.contributor.authorMartínez-Orellana, Pamela
dc.contributor.authorMartorell, Jaime M.
dc.contributor.authorBaratelli, Massimiliano
dc.contributor.authorMartínez, Jorge
dc.contributor.authorMigura-Garcia, Lourdes
dc.contributor.authorCórdoba, Lorena
dc.contributor.authorPérez, Mónica
dc.contributor.authorCasas, Inmaculada
dc.contributor.authorPozo, Francisco
dc.contributor.authorFraile, Lorenzo
dc.contributor.authorMajó, Natàlia
dc.contributor.authorMontoya, María
dc.contributor.otherProducció Animalca
dc.date.accessioned2020-09-02T09:08:19Z
dc.date.available2020-09-02T09:08:19Z
dc.date.issued2020-07-24
dc.identifier.citationVidaña, Beatriz, Pamela Martínez-Orellana, Jaime Martorell, Massimiliano Baratelli, Jorge Martínez, Lourdes Migura-Garcia, and Lorena Córdoba et al. 2020. "Differential Viral-Host Immune Interactions Associated With Oseltamivir-Resistant H275Y And Wild-Type H1N1 A(Pdm09) Influenza Virus Pathogenicity". Viruses 12 (8): 794. doi:10.3390/v12080794.ca
dc.identifier.issn1999-4915ca
dc.identifier.urihttp://hdl.handle.net/20.500.12327/899
dc.description.abstractOseltamivir is a common therapy against influenza A virus (IAV) infections. The acquisition of oseltamivir resistance (OR) mutations, such as H275Y, hampers viral fitness. However, OR H1N1 viruses have demonstrated the ability to spread throughout different populations. The objective of this work was to compare the fitness of two strains of OR (R6 and R7) containing the H275Y mutation, and a wild-type (F) pandemic influenza A (H1N1) 2009 (pdm09) virus both in vitro and in vivo in mice and to select one OR strain for a comparison with F in ferrets. R6 showed faster replication and pathogenicity than R7 in vitro and in mice. Subsequently, R6 was selected for the fitness comparison with the F strain in ferrets. Ferrets infected with the F virus showed more severe clinical signs, histopathological lung lesions, and viral quantification when compared to OR R6-infected animals. More importantly, differential viral kinetics correlated with differential pro-inflammatory host immune responses in the lungs of infected ferrets, where OR-infected animals developed a protective higher expression of type I IFN and Retinoid acid Inducible Gene I (RIG-I) genes early after infection, resulting in the development of milder disease. These results suggest the presence of early specific viral-host immune interactions relevant in the development of influenza-associated lung pathology.ca
dc.format.extent20ca
dc.language.isoengca
dc.publisherMDPIca
dc.relation.ispartofVirusesca
dc.rightsAttribution 4.0 Internationalca
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
dc.titleDifferential viral-host immune interactions associated with oseltamivir-resistant H275Y and wild-type H1N1 A(pdm09) influenza virus pathogenicityca
dc.typeinfo:eu-repo/semantics/articleca
dc.description.versioninfo:eu-repo/semantics/publishedVersionca
dc.rights.accessLevelinfo:eu-repo/semantics/openAccess
dc.embargo.termscapca
dc.relation.projectIDINIA/Programa Nacional de Proyectos de Investigación Fundamental/RTA2011‐00111‐C03-01/ES/Avian influenza: relationship between the host, the pathogen and the ecosystem/ca
dc.subject.udc619ca
dc.identifier.doihttps://doi.org/10.3390/v12080794ca
dc.contributor.groupSanitat Animalca


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Except where otherwise noted, this item's license is described as http://creativecommons.org/licenses/by/4.0/