Networks of inbreeding coefficients in a selected population of rabbits
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Author
Rodríguez‐Ramilo, Silvia T.
Reverter, Antonio
Sánchez, Juan P.
Fernández, Jesus
Velasco‐Galilea, Maria
González, Olga
Publication date
2020-08-17ISSN
0931-2668
Abstract
The correlation between pedigree and genomic‐based inbreeding coefficients is usually discussed in the literature. However, some of these correlations could be spurious. Using partial correlations and information theory, it is possible to distinguish a significant association between two variables which is independent from associations with a third variable. The objective of this study is to implement partial correlations and information theory to assess the relationship between different inbreeding coefficients using a selected population of rabbits. Data from pedigree and genomic information from a 200K SNP chip were available. After applying filtering criteria, the data set comprised 437 animals genotyped for 114,604 autosomal SNP. Fifteen pedigree‐ and genome‐based inbreeding coefficients were estimated and used to build a network. Recent inbreeding coefficient based on runs of homozygosity had 9 edges linking it with different inbreeding coefficients. Partial correlations and information theory approach allowed to infer meaningful associations between inbreeding coefficients and highlighted the importance of the recent inbreeding based on runs of homozygosity, but a good proxy of it could be those pedigree‐based definitions reflecting recent inbreeding.
Document Type
Article
Document version
Accepted version
Language
English
Subject (CDU)
575 - General genetics. General cytogenetics
59 - Zoology
619 - Veterinary science
636 - Animal husbandry and breeding in general. Livestock rearing. Breeding of domestic animals
Pages
31
Publisher
Wiley
Is part of
Journal of Animal Breeding and Genetics
Citation
Rodríguez‐Ramilo, Silvia T., Antonio Reverter, Juan P. Sánchez, Jesus Fernández, Maria Velasco‐Galilea, Olga González, and Miriam Piles. 2020. "Networks Of Inbreeding Coefficients In A Selected Population Of Rabbits". Journal Of Animal Breeding And Genetics 137 (6): 599-608. doi:10.1111/jbg.12500.
Grant agreement number
EC/H2020/633531/EU/Adapting the feed, the animal and the feeding techniques to improve the efficiency and sustainability of monogastric livestock production systems/Feed-a-Gene
INIA/Programa Estatal de I+D+I orientada a los retos de la sociedad/RTA2014-00015-C02-01/ES/Mejora de la eficiencia alimentaria en cerdos y conejos. Determinismo genético y estrategias de selección/
Program
Genètica i Millora Animal
This item appears in the following Collection(s)
- ARTICLES CIENTÍFICS [2510]
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Except where otherwise noted, this item's license is described as http://creativecommons.org/licenses/by-nc-nd/4.0/