Pathobiology of the highly pathogenic avian influenza viruses H7N1 and H5N8 in different chicken breeds and role of Mx 2032 G/A polymorphism in infection outcome
Visualitza/Obre
Autor/a
Sánchez-González, Raúl
Ramis, Antonio
Nofrarías, Miquel
Wali, Nabil
Valle, Rosa
Pérez, Mónica
Perlas, Albert
Majó, Natàlia
Data de publicació
2020-09-10ISSN
0928-4249
Resum
Chickens are highly susceptible to highly pathogenic avian infuenza viruses (HPAIVs). However, the severity of infec‑
tion varies depending of the viral strain and the genetic background of the host. In this study, we evaluated the
pathogenesis of two HPAIVs (H7N1 and H5N8) and assessed the susceptibility to the infection of local and com‑
mercial chicken breeds from Spain. Eight chicken breeds were intranasally inoculated with 105 ELD50 of A/Chicken/
Italy/5093/1999 (H7N1) or A/Goose/Spain/IA17CR02699/2017 (H5N8 clade 2.3.4.4. B) and monitored during 10 days.
Chickens were highly susceptible to both HPAIVs, but H7N1 was considerably more virulent than H5N8 as demon‑
strated by the highest mortality rates and shortest mean death times (MDT). Both HPAIVs produced severe necrosis
and intense viral replication in the central nervous system, heart and pancreas; however, the lesions and replication
in other tissues were virus-dependent. High levels of viral RNA were detected by the oral route with both viruses. In
contrast, a low number of H5N8-inoculated chickens shed by the cloacal route, demonstrating a diferent pattern of
viral shedding dependent of the HPAIV. We found a high variation in the susceptibility to HPAIVs between the diferent
chicken breeds. The birds carrying the genotype AA and AG at position 2032 in chicken Mx gene presented a slightly
higher, but not signifcant, percentage of survival and a statistically signifcant longer MDT than GG individuals. Our
study demonstrated that the severity of HPAI infection is largely dependent of the viral isolate and host factors, under‑
lining the complexity of HPAI infections
Tipus de document
Article
Versió del document
Versió publicada
Llengua
English
Matèries (CDU)
619 - Veterinària
Pàgines
13
Publicat per
BMC
Publicat a
Veterinary Research
Citació
Sánchez-González, Raúl, Antonio Ramis, Miquel Nofrarías, Nabil Wali, Rosa Valle, Mónica Pérez, Albert Perlas, and Natàlia Majó. 2020. "Pathobiology Of The Highly Pathogenic Avian Influenza Viruses H7N1 And H5N8 In Different Chicken Breeds And Role Of Mx 2032 G/A Polymorphism In Infection Outcome". Veterinary Research 51 (1). doi:10.1186/s13567-020-00835-4.
Número de l'acord de la subvenció
INIA/Programa Estatal de I+D+I orientada a los retos de la sociedad/RTA2015-00088-C03-03/ES/Influenza aviar: Estudio de la dinámica de la infección en aves autóctonas y de persistencia del virus en condiciones ambientales/
Programa
Sanitat Animal
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