Porcine reproductive and respiratory syndrome virus impacts on gut microbiome in a strain virulence‐dependent fashion
Visualitza/Obre
Autor/a
Argüello, Héctor
Rodríguez‐Gómez, Irene Magdalena
Sánchez‐Carvajal, Jose María
Pallares, Francisco José
Díaz, Iván
Cabrera‐Rubio, Raúl
Crispie, Fiona
Cotter, Paul D.
Mateu, Enric
Martín‐Valls, Gerard
Carrasco, Librado
Gómez‐Laguna, Jaime
Data de publicació
2021-03-03ISSN
1751-7915
Resum
Porcine reproductive and respiratory syndrome (PRRS) is a viral disease defined by reproductive problems, respiratory distress and a negative impact on growth rate and general condition. Virulent PRRS virus (PRRSV) strains have emerged in the last years with evident knowledge gaps in their impact on the host immune response. Thus, the present study examines the impact of acute PRRS virus (PRRSV) infection, with two strains of different virulence, on selected immune parameters and on the gut microbiota composition of infected pigs using 16S rRNA compositional sequencing. Pigs were infected with a low virulent (PRRS_3249) or a virulent (Lena) PRRSV‐1 strain and euthanized at 1, 3, 6, 8 or 13 days post‐inoculation (dpi). Faeces were collected from each animal at the necropsy time‐point. Alpha and beta diversity analyses demonstrated that infection, particularly with the Lena strain, impacted the microbiome composition from 6 dpi onwards. Taxonomic differences revealed that infected pigs had higher abundance of Treponema and Methanobrevibacter (FDR < 0.05). Differences were more considerable for Lena‐ than for PRRS_3249‐infected pigs, showing the impact of strain virulence in the intestinal changes. Lena‐infected pigs had reduced abundancies of anaerobic commensals such as Roseburia, Anaerostipes, Butyricicoccus and Prevotella (P < 0.05). The depletion of these desirable commensals was significantly correlated to infection severity measured by viraemia, clinical signs, lung lesions and immune parameters (IL‐6, IFN‐γ and Hp serum levels). Altogether, the results from this study demonstrate the indirect impact of PRRSV infection on gut microbiome composition in a strain virulence‐dependent fashion and its association with selected immune markers.
Tipus de document
Article
Versió del document
Versió publicada
Llengua
English
Matèries (CDU)
619 - Veterinària
Pàgines
10
Publicat per
Wiley Open Access
Publicat a
Microbial Biotechnology
Citació
Argüello, Héctor, Irene Magdalena Rodríguez‐Gómez, Jose María Sánchez‐Carvajal, Francisco José Pallares, Iván Díaz, Raúl Cabrera‐Rubio, and Fiona Crispie et al. 2022. "Porcine Reproductive And Respiratory Syndrome Virus Impacts On Gut Microbiome In A Strain Virulence‐Dependent Fashion". Microbial Biotechnology 15 (3): 1007-1016 . doi:10.1111/1751-7915.13757.
Número de l'acord de la subvenció
MINECO/Programa Estatal de promoción del talento y su empleabilidad en I+D+I/RYC-2014-16735/ES/ /
MINECO/Programa Estatal de I+D+I orientada a los retos de la sociedad/AGL2016-76111-R/ES/Caracterización del transcriptoma del macrófago alveolar porcino en las fases tempranas de la infección in vivo con cepas del virus del PRRS-1 de distinta virulencia/
EC/H2020/818368/EU/Microbiome Applications for Sustainable food systems through Technologies and EnteRprise/MASTER
Programa
Sanitat Animal
Aquest element apareix en la col·lecció o col·leccions següent(s)
- ARTICLES CIENTÍFICS [2831]
Excepte que s'indiqui una altra cosa, la llicència de l'ítem es descriu com http://creativecommons.org/licenses/by-nc-nd/4.0/