SARS-CoV-2 infection elicits a rapid neutralizing antibody response that correlates with disease severity
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Autor/a
Trinité, Benjamin
Tarrés-Freixas, Ferran
Rodon, Jordi
Pradenas, Edwards
Urrea, Víctor
Marfil, Silvia
Rodríguez de la Concepción, María Luisa
Ávila-Nieto, Carlos
Aguilar-Gurrieri, Carmen
Barajas, Ana
Ortiz, Raquel
Paredes, Roger
Mateu, Lourdes
Valencia, Alfonso
Guallar, Víctor
Ruiz, Lidia
Grau, Eulàlia
Massanella, Marta
Puig, Jordi
Chamorro, Anna
Izquierdo-Useros, Nuria
Clotet, Bonaventura
Carrillo, Jorge
Vergara-Alert, Júlia
Blanco, Julià
Fecha de publicación
2021-01-28ISSN
2045-2322
Resumen
The protective effect of neutralizing antibodies in SARS-CoV-2 infected individuals is not yet well defined. To address this issue, we have analyzed the kinetics of neutralizing antibody responses and their association with disease severity. Between March and May 2020, the prospective KING study enrolled 72 COVID-19+ participants grouped according to disease severity. SARS-CoV-2 infection was diagnosed by serological and virological tests. Plasma neutralizing responses were assessed against replicative virus and pseudoviral particles. Multiple regression and non-parametric tests were used to analyze dependence of parameters. The magnitude of neutralizing titers significantly increased with disease severity. Hospitalized individuals developed higher titers compared to mild-symptomatic and asymptomatic individuals, which together showed titers below the detection limit in 50% of cases. Longitudinal analysis confirmed the strong differences in neutralizing titers between non-hospitalized and hospitalized participants and showed rapid kinetics of appearance of neutralizing antibodies (50% and 80% of maximal activity reached after 11 and 17 days after symptoms onset, respectively) in hospitalized patients. No significant impact of age, gender or treatment on the neutralizing titers was observed in this limited cohort. These data identify a clear association of humoral immunity with disease severity and point to immune mechanisms other than antibodies as relevant players in COVID-19 protection.
Tipo de documento
Artículo
Versión del documento
Versión publicada
Lengua
English
Materias (CDU)
619 - Veterinaria
Páginas
10
Publicado por
Nature Research
Publicado en
Scientific Reports
Citación
Trinité, Benjamin, Ferran Tarrés-Freixas, Jordi Rodon, Edwards Pradenas, Víctor Urrea, Silvia Marfil, and María Luisa Rodríguez de la Concepción et al. 2021. "SARS-Cov-2 Infection Elicits A Rapid Neutralizing Antibody Response That Correlates With Disease Severity". Scientific Reports 11 (1). doi:10.1038/s41598-021-81862-9.
Program
Sanitat Animal
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