Toxicity Screening of a Gambierdiscus australes Strain from the Western Mediterranean Sea and Identification of a Novel Maitotoxin Analogue
Visualitza/Obre
Autor/a
Estevez, Pablo
Castro, David
Leäo-Martins, José Manuel
Sibat, Manoëlla
Tudó, Angels
Dickey, Robert
Diogene, Jorge
Hess, Philipp
Gago-Martinez, Ana
Data de publicació
2021-08-15ISSN
1660-3397
Resum
Dinoflagellate species of the genera Gambierdiscus and Fukuyoa are known to produce ciguatera poisoning-associated toxic compounds, such as ciguatoxins, or other toxins, such as maitotoxins. However, many species and strains remain poorly characterized in areas where they were recently identified, such as the western Mediterranean Sea. In previous studies carried out by our research group, a G. australes strain from the Balearic Islands (Mediterranean Sea) presenting MTX-like activity was characterized by LC-MS/MS and LC-HRMS detecting 44-methyl gambierone and gambieric acids C and D. However, MTX1, which is typically found in some G. australes strains from the Pacific Ocean, was not detected. Therefore, this study focuses on the identification of the compound responsible for the MTX-like toxicity in this strain. The G. australes strain was characterized not only using LC-MS instruments but also N2a-guided HPLC fractionation. Following this approach, several toxic compounds were identified in three fractions by LC-MS/MS and HRMS. A novel MTX analogue, named MTX5, was identified in the most toxic fraction, and 44-methyl gambierone and gambieric acids C and D contributed to the toxicity observed in other fractions of this strain. Thus, G. australes from the Mediterranean Sea produces MTX5 instead of MTX1 in contrast to some strains of the same species from the Pacific Ocean. No CTX precursors were detected, reinforcing the complexity of the identification of CTXs precursors in these regions.
Tipus de document
Article
Versió del document
Versió publicada
Llengua
English
Matèries (CDU)
574 - Ecologia general i biodiversitat
Pàgines
19
Publicat per
MDPI
Publicat a
Marine Drugs
Citació
Estevez, Pablo, David Castro, José Manuel Leão-Martins, Manoëlla Sibat, Angels Tudó, Robert Dickey, Jorge Diogene, Philipp Hess, and Ana Gago-Martinez. 2021. "Toxicity Screening Of A Gambierdiscus Australes Strain From The Western Mediterranean Sea And Identification Of A Novel Maitotoxin Analogue". Marine Drugs 19 (8): 460. doi:10.3390/md19080460.
Número de l'acord de la subvenció
EFSA/ /GP-EFSA-AFSCO-2015-03/EU/Risk Characterization of Ciguatera Food Poisoning in Europe/EUROCIGUA
Programa
Aigües Marines i Continentals
Aquest element apareix en la col·lecció o col·leccions següent(s)
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