Effect of spray-drying and ultraviolet C radiation as biosafety steps for CSFV and ASFV inactivation in porcine plasma
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Autor/a
Blázquez, Elena
Rodríguez, Carmen
Ródenas, Jesús
Polo, Javier
Fecha de publicación
2021-04-28ISSN
1932-6203
Resumen
Spray-dried animal plasma (SDAP) is widely used in diets of domestic animals to improve health status and increase growth and feed efficiency. Individual steps in the SDAP manufacturing process, including spray-drying, have been validated to inactivate potential pathogens. Manufacturing standards have established a minimum exit temperature of 80°C and a minimum post-drying storage period of 14 days at 20°C for production of SDAP. Also, UV-C irradiation has been evaluated as another inactivation step that could be included in the manufacturing process. The aim of this study was to assess the inactivation effectiveness of spray-drying on Classical swine fever virus (CSFV) and African swine fever virus (ASFV) and the effect of UV-C inactivation on ASFV as redundant biosafety steps of the manufacturing process for producing spray-dried porcine plasma (SDPP). This study demonstrated that UV-C treatment of liquid porcine plasma can inactivate more than 4 Log10 TCID50/mL of ASFV at 3000 J/L. Spray-drying effectively inactivated at least 4 Log10 TCID50/mL of both CSFV and ASFV. Incorporating UV-C technology within the SDAP manufacturing process can add another biosafety step to further enhance product safety.
Tipo de documento
Artículo
Versión del documento
Versión publicada
Lengua
Inglés
Materias (CDU)
619 - Veterinaria
Páginas
11
Publicado por
Public Library of Science
Publicado en
PLoS ONE
Citación
Blázquez, Elena, Carmen Rodríguez, Jesús Ródenas, Rosa Rosell, Joaquim Segalés, Joan Pujols, and Javier Polo. 2021. "Effect Of Spray-Drying And Ultraviolet C Radiation As Biosafety Steps For CSFV And ASFV Inactivation In Porcine Plasma". PLOS ONE 16 (4): e0249935. doi:10.1371/journal.pone.0249935.
Program
Sanitat Animal
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