Sow vaccination against virulent Glaesserella parasuis shapes the nasal microbiota of their offspring
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Autor/a
Correa-Fiz, Florencia
Fecha de publicación
2022-03-01ISSN
2045-2322
Resumen
Glaesserella parasuis is the etiological agent of Glässer’s disease, a common pathology in the pork industry with higher prevalence in the postweaning period. Vaccination is one of the strategies to control this disease. Here, we investigated the effect that sow vaccination against virulent strains of G. parasuis had in the nasal microbiota of their offspring. Nasal swabs from fifteen days-old piglets from vaccinated (vs-P, n = 11) and unvaccinated sows (cs-P, n = 11) were obtained and DNA was extracted for 16S amplicon sequencing. Microbiota composition was different, with lower diversity in vs-P, and a strong clustering of the groups in beta diversity analysis. Among the 1509 sequences associated to either study group, all the sequences classified as G. parasuis (10 ASVs) had lower relative abundance in the vs-P group. A list of 32 inferred metabolic pathways were statistically different between groups. A distinctive structure of the two microbial networks was detected, with modules in the cs-P not conserved in the vs-P network. In conclusion, vaccination of the sows had a large effect in the microbiota composition of their offspring that went beyond the effect on the targeted pathogen. The mechanisms underneath these changes may include alteration of the microbiota network due to the elimination of the targeted pathogen and/or immunological changes.
Tipo de documento
Artículo
Versión del documento
Versión publicada
Lengua
Inglés
Páginas
10
Publicado por
Nature Research
Publicado en
Scientific Reports
Citación
Blanco-Fuertes, Miguel, Florencia Correa-Fiz, Sergi López-Serrano, Marina Sibila, and Virginia Aragon. 2022. "Sow Vaccination Against Virulent Glaesserella Parasuis Shapes The Nasal Microbiota Of Their Offspring". Scientific Reports 12 (1). doi:10.1038/s41598-022-07382-2.
Número del acuerdo de la subvención
MINECO/Programa Estatal de I+D+I orientada a los retos de la sociedad/AGL2016-77361-R/ES/PAPEL DE LA MICROBIOTA RESPIRATORIA EN LA PREVENCION DE LAS ENFERMEDADES CAUSADAS POR LOS COLONIZADORES PRECOCES DEL TRACTO RESPIRATORIO SUPERIOR DEL CERDO/
MICIU/Programa Estatal de generación del conocimiento y fortalecimiento científico y tecnológico del sistema I+D+I y Programa Estatal de I+D+I orientada a los retos de la sociedad/PID2019-106233RB-I00/ES/FUNCIONALIDAD Y EFECTO DE LA MICROBIOTA NASAL SOBRE LA RESPUESTA INMUNE DE LOS LECHONES/
Program
Sanitat Animal
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