Gain-of-function mutations in Aqp3a influence zebrafish pigment pattern formation through the tissue environment
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Autor/a
Eskova, Anastasia
Chauvigné, Francois
Maischein, Hans-Martin
Ammelburg, Moritz
Nüsslein-Volhard, Christiane
Irion, Uwe
Fecha de publicación
2017-06-01ISSN
0950-1991
Resumen
The development of the pigmentation pattern in zebrafish is a tightly regulated process that depends on both the self-organizing properties of pigment cells and extrinsic cues from other tissues. Many of the
known mutations that alter the pattern act cell-autonomously in pigment cells, and our knowledge about external regulators is limited. Here, we describe novel zebrafish mau mutants, which encompass several dominant missense mutations in Aquaporin 3a (Aqp3a) that lead to broken stripes and short fins. A loss-of-function aqp3a allele, generated by CRISPR-Cas9, has no phenotypic consequences, demonstrating that Aqp3a is dispensable for normal development. Strikingly, the pigment cells from dominant mau mutants are capable of forming a wild-type pattern when developing in a wild-type environment, but the surrounding tissues in the mutants influence pigment cell behaviour and interfere with the patterning process. The mutated amino acid residues in the dominant alleles line the pore surface of Aqp3a and influence pore permeability. These results demonstrate an important effect of the tissue environment on pigment cell behaviour and, thereby, on pattern formation.
Tipo de documento
Artículo
Versión del documento
Versión publicada
Lengua
English
Materias (CDU)
639 - Caza. Pesca. Piscicultura
Páginas
11
Publicado por
The Company of Biologists
Publicado en
Development
Citación
Eskova, Anastasia, Francois Chauvigné, Hans-Martin Maischein, Moritz Ammelburg, Joan Cerdà, Christiane Nüsslein-Volhard, and Uwe Irion. 2017. "Gain-Of-Function Mutations Aqp3a Influence Zebrafish Pigment Pattern Formation Through The Tissue Environment". Development. doi:10.1242/dev.143495.
Program
Aqüicultura
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