Protective effect of a polyvalent influenza DNA vaccine in pigs
Ver/Abrir
Autor/a
Karlsson, Ingrid
Borggren, Marie
Rosenstierne, Maiken Worsøe
Trebbien, Ramona
Williams, James A.
Vergara-Alert, Júlia
Solanes Foz, David
Sisteré-Oró, Marta
Nielsen, Jens
Fomsgaard, Anders
Fecha de publicación
2017-11-23ISSN
0165-2427
Resumen
Background: Influenza A virus in swine herds represents a major problem for the swine industry and poses a
constant threat for the emergence of novel pandemic viruses and the development of more effective influenza
vaccines for pigs is desired. By optimizing the vector backbone and using a needle-free delivery method, we have
recently demonstrated a polyvalent influenza DNA vaccine that induces a broad immune response, including
both humoral and cellular immunity.
Objectives: To investigate the protection of our polyvalent influenza DNA vaccine approach in a pig challenge
study.
Methods: By intradermal needle-free delivery to the skin, we immunized pigs with two different doses (500 μg
and 800 μg) of an influenza DNA vaccine based on six genes of pandemic origin, including internally expressed
matrix and nucleoprotein and externally expressed hemagglutinin and neuraminidase as previously demonstrated.
Two weeks following immunization, the pigs were challenged with the 2009 pandemic H1N1 virus.
Results: When challenged with 2009 pandemic H1N1, 0/5 vaccinated pigs (800 μg DNA) became infected
whereas 5/5 unvaccinated control pigs were infected. The pigs vaccinated with the low dose (500 μg DNA) were
only partially protected. The DNA vaccine elicited binding-, hemagglutination inhibitory (HI) − as well as crossreactive
neutralizing antibody activity and neuraminidase inhibiting antibodies in the immunized pigs, in a dosedependent
manner.
Conclusion: The present data, together with the previously demonstrated immunogenicity of our influenza DNA
vaccine, indicate that naked DNA vaccine technology provides a strong approach for the development of improved
pig vaccines, applying realistic low doses of DNA and a convenient delivery method for mass vaccination.
Tipo de documento
Artículo
Versión del documento
Versión publicada
Lengua
English
Materias (CDU)
619 - Veterinaria
Páginas
8
Publicado por
Elsevier
Publicado en
Veterinary Immunology and Immunopathology
Citación
Karlsson, Ingrid, Marie Borggren, Maiken Worsøe Rosenstierne, Ramona Trebbien, James A. Williams, Enric Vidal, and Júlia Vergara-Alert et al. 2018. "Protective Effect Of A Polyvalent Influenza DNA Vaccine In Pigs". Veterinary Immunology And Immunopathology 195: 25-32. Elsevier BV. doi:10.1016/j.vetimm.2017.11.007.
Número del acuerdo de la subvención
EC/FP7/602012/EU/Universal Influenza Vaccines Secured/UNISEC
Program
Sanitat Animal
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