Genomic analysis of sewage from 101 countries reveals global landscape of antimicrobial resistance
Visualitza/Obre
Autor/a
Munk, Patrick
Brinch, Christian
Møller, Frederik Duus
Petersen, Thomas N.
Hendriksen, Rene S.
Seyfarth, Anne Mette
Kjeldgaard, Jette S.
Svendsen, Christina Aaby
van Bunnik, Bram
Berglund, Fanny
Global Sewage Surveillance Consortium
Larsson, D. G. Joakim
Koopmans, Marion
Woolhouse, Mark
Aarestrup, Frank M.
Data de publicació
2022-12-01ISSN
2041-1723
Resum
Antimicrobial resistance (AMR) is a major threat to global health. Understanding the emergence, evolution, and transmission of individual antibiotic resistance genes (ARGs) is essential to develop sustainable strategies combatting this threat. Here, we use metagenomic sequencing to analyse ARGs in 757 sewage samples from 243 cities in 101 countries, collected from 2016 to 2019. We find regional patterns in resistomes, and these differ between subsets corresponding to drug classes and are partly driven by taxonomic variation. The genetic environments of 49 common ARGs are highly diverse, with most common ARGs carried by multiple distinct genomic contexts globally and sometimes on plasmids. Analysis of flanking sequence revealed ARG-specific patterns of dispersal limitation and global transmission. Our data furthermore suggest certain geographies are more prone to transmission events and should receive additional attention.
Tipus de document
Article
Versió del document
Versió publicada
Llengua
English
Matèries (CDU)
619 - Veterinària
Pàgines
16
Publicat per
Nature Research
Publicat a
Nature Communications
Citació
Munk, Patrick, Christian Brinch, Frederik Duus Møller, Thomas N. Petersen, Rene S. Hendriksen, Anne Mette Seyfarth, and Jette S. Kjeldgaard et al. 2022. "Genomic Analysis Of Sewage From 101 Countries Reveals Global Landscape Of Antimicrobial Resistance". Nature Communications 13 (1). doi:10.1038/s41467-022-34312-7.
Número de l'acord de la subvenció
EC/H2020/874735/EU/Versatile Emerging infectious disease Observatory/VEO
Programa
Sanitat Animal
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