Genomic analysis of sewage from 101 countries reveals global landscape of antimicrobial resistance
Ver/Abrir
Autor/a
Munk, Patrick
Brinch, Christian
Møller, Frederik Duus
Petersen, Thomas N.
Hendriksen, Rene S.
Seyfarth, Anne Mette
Kjeldgaard, Jette S.
Svendsen, Christina Aaby
van Bunnik, Bram
Berglund, Fanny
Global Sewage Surveillance Consortium
Larsson, D. G. Joakim
Koopmans, Marion
Woolhouse, Mark
Aarestrup, Frank M.
Fecha de publicación
2022-12-01ISSN
2041-1723
Resumen
Antimicrobial resistance (AMR) is a major threat to global health. Understanding the emergence, evolution, and transmission of individual antibiotic resistance genes (ARGs) is essential to develop sustainable strategies combatting this threat. Here, we use metagenomic sequencing to analyse ARGs in 757 sewage samples from 243 cities in 101 countries, collected from 2016 to 2019. We find regional patterns in resistomes, and these differ between subsets corresponding to drug classes and are partly driven by taxonomic variation. The genetic environments of 49 common ARGs are highly diverse, with most common ARGs carried by multiple distinct genomic contexts globally and sometimes on plasmids. Analysis of flanking sequence revealed ARG-specific patterns of dispersal limitation and global transmission. Our data furthermore suggest certain geographies are more prone to transmission events and should receive additional attention.
Tipo de documento
Artículo
Versión del documento
Versión publicada
Lengua
English
Materias (CDU)
619 - Veterinaria
Páginas
16
Publicado por
Nature Research
Publicado en
Nature Communications
Citación
Munk, Patrick, Christian Brinch, Frederik Duus Møller, Thomas N. Petersen, Rene S. Hendriksen, Anne Mette Seyfarth, and Jette S. Kjeldgaard et al. 2022. "Genomic Analysis Of Sewage From 101 Countries Reveals Global Landscape Of Antimicrobial Resistance". Nature Communications 13 (1). doi:10.1038/s41467-022-34312-7.
Número del acuerdo de la subvención
EC/H2020/874735/EU/Versatile Emerging infectious disease Observatory/VEO
Program
Sanitat Animal
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