Milk fat globule membrane plus milk fat increase docosahexaenoic acid availability in infant formulas
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Author
Gázquez, Antonio
Sabater-Molina, María
Domínguez-López, Inés
Sánchez-Campillo, María
Tibau , Joan
Moreno-Muñoz, José A.
Rodríguez-Palmero, María
López-Sabater, María C.
Larqué, Elvira
Publication date
2022-10-25ISSN
1436-6207
Abstract
Purpose
Milk fat globule membrane (MFGM) has components with emulsifier properties that could affect the provision of substrates to the brain. We evaluated the effects of MFGM plus milk fat addition to infant formulas on docosahexaenoic acid (DHA) availability and gut development.
Methods
In Experiment 1, suckling piglets were divided into 3 groups: Group L1 (n = 8): fed with a vegetal fat formula with palm oil; L2 (n = 8): canola oil formula and L3 (n = 8): milk fat + canola oil + 1% Lacprodan (3% MFGM of total protein content). In Experiment 2, Group L4 (n = 7): fed with canola oil + 1% Lacprodan (3% MFGM) and Group L5 (n = 5): milk fat + canola oil + 2% Lacprodan (6% MFGM). All formulas contained 0.2% DHA and 0.2% arachidonic acid.
Results
In Experiment 1, DHA was similar among the groups in both total fatty acids and plasma phospholipids (PL). However, 3% MFGM (L3) increased significantly the proportion of DHA and LC-PUFA n-3 in liver total fatty acids, jejunum, and also in jejunum PL respect to the other formulas. There were no changes in gut histology, cell proliferation, apoptosis, or brain DHA content. In Experiment 2, higher MFGM dose was used. Then, higher DHA was not only found in peripheral tissues of 6% MFGM (L5) piglets but also in plasma PL, while a similar trend was observed in cortex PL (p = 0.123).
Conclusion
In conclusion, MFGM plus milk fat may increase DHA availability of infant formulas which could contribute to their beneficial health effects.
Document Type
Article
Document version
Published version
Language
English
Subject (CDU)
663/664 - Food and nutrition. Enology. Oils. Fat
Pages
13
Publisher
Springer
Is part of
European Journal of Nutrition
Citation
Gázquez, Antonio, María Sabater-Molina, Inés Domínguez-López, María Sánchez-Campillo, Neus Torrento, Joan Tibau, José A. Moreno-Muñoz, María Rodríguez-Palmero, María C. López-Sabater, and Elvira Larqué. 2022. "Milk Fat Globule Membrane Plus Milk Fat Increase Docosahexaenoic Acid Availability In Infant Formulas". European Journal Of Nutrition. doi:10.1007/s00394-022-03024-5.
Grant agreement number
CDTI-FEDER/ /IDI-20141206/ES/ /SMARTFOODS
Program
Genètica i Millora Animal
This item appears in the following Collection(s)
- ARTICLES CIENTÍFICS [2831]
Except where otherwise noted, this item's license is described as http://creativecommons.org/licenses/by/4.0/