Preclinical evaluation of PHH-1V vaccine candidate against SARS-CoV-2 in non-human primates
Ver/Abrir
Autor/a
Prenafeta, Antoni
Bech-Sàbat, Gregori
Moros, Alexandra
Barreiro, Antonio
Fernández, Alex
Cañete, Manuel
Roca, Mercè
González-González, Luis
Garriga, Carme
Confais, Joachim
Toussenot, Marion
Contamin, Hugues
Pizzorno, Andrés
Rosa-Calatrava, Manuel
Pradenas, Edwards
Marfil, Silvia
Blanco, Julià
Cebollada Rica, Paula
Sisteré-Oró, Marta
Meyerhans, Andreas
Lorca, Cristina
Prat, Teresa
March, Ricard
Ferrer, Laura
Fecha de publicación
2023-06-28ISSN
2589-0042
Resumen
SARS-CoV-2 emerged in December 2019 and quickly spread worldwide, continuously striking with an unpredictable evolution. Despite the success in vaccine production and mass vaccination programs, the situation is not still completely controlled, and therefore accessible second-generation vaccines are required to mitigate the pandemic. We previously developed an adjuvanted vaccine candidate coded PHH-1V, based on a heterodimer fusion protein comprising the RBD domain of two SARS-CoV-2 variants. Here, we report data on the efficacy, safety, and immunogenicity of PHH-1V in cynomolgus macaques. PHH-1V prime-boost vaccination induces high levels of RBD-specific IgG binding and neutralizing antibodies against several SARS-CoV-2 variants, as well as a balanced Th1/Th2 cellular immune response. Remarkably, PHH-1V vaccination prevents SARS-CoV-2 replication in the lower respiratory tract and significantly reduces viral load in the upper respiratory tract after an experimental infection. These results highlight the potential use of the PHH-1V vaccine in humans, currently undergoing Phase III clinical trials.
Tipo de documento
Artículo
Versión del documento
Versión publicada
Lengua
English
Materias (CDU)
619 - Veterinaria
Páginas
25
Publicado por
Cell Press
Publicado en
iScience
Citación
Prenafeta, Antoni, Gregori Bech-Sàbat, Alexandra Moros, Antonio Barreiro, Alex Fernández, Manuel Cañete, Mercè Roca, Luis González-González, Carme Garriga, Joachim Confais, Marion Toussenot, Hugues Contamin, Andrés Pizzorno, Manuel Rosa-Calatrava, Edwards Pradenas, Silvia Marfil, Julià Blanco, Paula Cebollada Rica, Marta Sisteré-Oró, Andreas Meyerhans, Cristina Lorca, Joaquim Segalés, Teresa Prat, Ricard March, and Laura Ferrer. 2023. "Preclinical Evaluation Of PHH-1V Vaccine Candidate Against SARS-Cov-2 In Non-Human Primates". Iscience 26 (7): 107224. doi:10.1016/j.isci.2023.107224.
Número del acuerdo de la subvención
CDTI/ /IDI-20210115/ES/ /
Program
Sanitat Animal
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