Pre-calving intravaginal administration of lactic acid bacteria reduces metritis prevalence and regulates blood neutrophil gene expression after calving in dairy cattle
Visualitza/Obre
Autor/a
Genís, Sandra
Cerri, Ronaldo L. A.
Bach, Àlex
Silper, Bruna F.
Baylão, Matheus
Denis-Robichaud, José
Arís, Anna
Data de publicació
2018-06-21ISSN
2297-1769
Resum
Metritis affects up to 40% of dairy cows and it is usually treated with antibiotics. In
spite of their advantages, there is an increased concern about antibiotic resistance
leading to the research of alternative methods. The aim of this study was to evaluate
the effects of a combination of lactic acid bacteria (LAB) on the prevalence of metritis
and modulation of endometrial and neutrophil inflammatory markers in dairy cows. One
hundred and thirty-five cows were enrolled 3 week before calving and randomly assigned
to three treatments. Treatment groups were: (1) two intravaginal doses of LAB/wk during
3 week pre-calving (vaginal, n = 45); (2) an intra-uterine dose, once 1 d after calving
(uterine, n = 44); and (3) no intervention (CTRL, n = 45). Metritis was defined as body
temperature > 39.5◦C and purulent vaginal discharge (> 50% pus), and diagnosed
6 d after calving. Blood samples were taken at d −14, −10, −7, −4, +1, +3, +6,
and +14 relative to calving for non-esterified fatty acids (NEFA) analysis. At d −10,
+1, +3, and +6 neutrophils were isolated from blood for gene expression analysis
by RT-qPCR. Endometrium biopsies were taken from 30 cows, 15 from CTRL and 15
from the uterine group at d +1, +3, and +6 after calving for pro-inflammatory markers
analysis by NanoString®. Vaginal treatment reduced metritis prevalence (6/45) up to
58% compared with CTRL group (14/45), but there was no difference between the
uterine and CTRL group. Uterine and vaginal treatments reduced blood neutrophil gene
expression. Expression of pro-inflammatory markers in the endometrium did not differ
between uterine and CTRL cows. Metritic cows expressed more C-X-C motif chemokine
ligand 8 (CXCL8) and interleukin 1 beta (IL1B) at d 3 than healthy cows, whereas healthy
cows expressed more CXCL8 at d 1 relative to calving in the endometrium. This study
shows a promising potential of LAB probiotics as a preventive treatment against metritis
in dairy cows.
Tipus de document
Article
Versió del document
Versió publicada
Llengua
English
Pàgines
10
Publicat per
Frontiers Media
Publicat a
Frontiers in Veterinary Science
Citació
Genís, Sandra, Ronaldo L. A. Cerri, Àlex Bach, Bruna F. Silper, Matheus Baylão, José Denis-Robichaud, and Anna Arís. 2018. "Pre-Calving Intravaginal Administration Of Lactic Acid Bacteria Reduces Metritis Prevalence And Regulates Blood Neutrophil Gene Expression After Calving In Dairy Cattle". Frontiers In Veterinary Science 5. Frontiers Media SA. doi:10.3389/fvets.2018.00135.
Programa
Producció de Remugants
Aquest element apareix en la col·lecció o col·leccions següent(s)
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