PigBiobank: a valuable resource for understanding genetic and biological mechanisms of diverse complex traits in pigs
Ver/Abrir
Autor/a
Zeng, Haonan
Zhang, Wenjing
Lin, Qing
Gao, Yahui
Teng, Jinyan
Xu, Zhiting
Cai, Xiaodian
Zhong, Zhanming
Wu, Jun
Liu, Yuqiang
Diao, Shuqi
Wei, Chen
Gong, Wentao
Pan, Xiangchun
Li, Zedong
Huang, Xiaoyu
Chen, Xifan
Du, Jinshi
The PigGTEx Consortium
Zhao, Fuping
Zhao, Yunxiang
Amills, Marcel
Clop, Alex
Karlskov-Mortensen, Peter
Fredholm, Merete
Li, Pinghua
Huang, Ruihua
Tang, Guoqing
Li, Mingzhou
Liu, Xiaohong
Chen, Yaosheng
Zhang, Qin
Li, Jiaqi
Yuan, Xiaolong
Ding, Xiangdong
Fang, Lingzhao
Zhang, Zhe
Fecha de publicación
2023-11-13ISSN
0305-1048
Resumen
To fully unlock the potential of pigs as both agricultural species for animal-based protein food and biomedical models for human biology and disease, a comprehensive understanding of molecular and cellular mechanisms underlying various complex phenotypes in pigs and how the findings can be translated to other species, especially humans, are urgently needed. Here, within the Farm animal Genotype-Tissue Expression (FarmGTEx) project, we build the PigBiobank (http://pigbiobank.farmgtex.org) to systematically investigate the relationships among genomic variants, regulatory elements, genes, molecular networks, tissues and complex traits in pigs. This first version of the PigBiobank curates 71 885 pigs with both genotypes and phenotypes from over 100 pig breeds worldwide, covering 264 distinct complex traits. The PigBiobank has the following functions: (i) imputed sequence-based genotype-phenotype associations via a standardized and uniform pipeline, (ii) molecular and cellular mechanisms underlying trait-associations via integrating multi-omics data, (iii) cross-species gene mapping of complex traits via transcriptome-wide association studies, and (iv) high-quality results display and visualization. The PigBiobank will be updated timely with the development of the FarmGTEx-PigGTEx project, serving as an open-access and easy-to-use resource for genetically and biologically dissecting complex traits in pigs and translating the findings to other species.
Tipo de documento
Artículo
Versión del documento
Versión publicada
Lengua
Inglés
Materias (CDU)
57 - Biología
Páginas
10
Publicado por
Oxford University Press
Publicado en
Nucleic Acids Research
Citación
Zeng, Haonan, Wenjing Zhang, Qing Lin, Yahui Gao, Jinyan Teng, Zhiting Xu, Xiaodian Cai, et al. 2023. “PigBiobank: A Valuable Resource for Understanding Genetic and Biological Mechanisms of Diverse Complex Traits in Pigs.” Nucleic Acids Research 52(D1): D980–D989. doi.org/10.1093/nar/gkad1080.
Program
Genètica i Millora Animal
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