MicroRNA expression in specific segments of the pig periovulatory internal genital tract is differentially regulated by semen or by seminal plasma
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Autor/a
Alvarez-Rodríguez, Manuel
Martinez-Serrano, Cristina A.
Nieto, Helena
de Mercado, Eduardo
Rodríguez-Martínez, Heriberto
Fecha de publicación
2024-01-02ISSN
0034-5288
Resumen
microRNAs play pivotal roles during mammalian reproduction, including the cross-talk between gametes, embryos and the maternal genital tract. Mating induces changes in the expression of mRNA transcripts in the female, but whether miRNAs are involved remains to be elucidated. In the current study, we mapped 181 miRNAs
in the porcine peri-ovulatory female reproductive tract: Cervix (Cvx), distal and proximal uterus (Dist-Ut, ProxUt), Utero-tubal-junction (UTJ), isthmus (Isth), ampulla (Amp), and infundibulum (Inf) when exposed to semen
(natural mating (NM) or artificial insemination (AI-P1)) or to infusions of sperm-free seminal plasma (SP): the
first 10 mL of the sperm rich fraction (SP-P1) or the entire ejaculate (SP-E). Among the most interesting findings,
NM decreased mir-671, implicated in uterine development and pregnancy loss prior to embryo implantation, in
Cvx, Dist-UT, Prox-UT, Isth, and Inf, while it increased in Amp. NM and SP-E induced the downregulation of miRlet7A-1 (Dist-UT, Prox-UT), a regulator of immunity during pregnancy. miR-34C-1, a regulator of endometrial
receptivity gene expression, was increased in Dist-UT, UTJ and Amp (NM), in Prox-UT (AI-P1), and in Amp (SPP1). miR-296, a modulator of the inflammatory response and apoptosis, was upregulated in the UTJ (all treatments). NM elicited the highest miRNA activity in the sperm reservoir (UTJ), suggesting that key-regulators such
as miR-34c or miR-296 may modulate the metabolic processes linked to the adequate preparation for gamete
encounter in the oviduct. Our results suggest that SP should be maintained in AI to warrant miRNA regulation
within the female genital tract for reproductive success.
Tipo de documento
Artículo
Versión del documento
Versión publicada
Lengua
English
Materias (CDU)
619 - Veterinaria
Páginas
12
Publicado por
Elsevier
Publicado en
Research in Veterinary Science
Citación
Álvarez‐Rodríguez, Manuel, Cristina A. Martinez-Serrano, Jaume Gardela, Héctor Nieto, E. De Mercado, and H. Rodríguez‐Martínez. 2024. “MicroRNA Expression in Specific Segments of the Pig Periovulatory Internal Genital Tract Is Differentially Regulated by Semen or by Seminal Plasma.” Research in Veterinary Science 168: 105134. doi:10.1016/j.rvsc.2023.105134.
Número del acuerdo de la subvención
MICINN/Programa Estatal de promoción del talento y su empleabilidad en I+D+I/RYC2020-028715-I/ES/ /
MICIU/Programa Estatal de generación del conocimiento y fortalecimiento científico y tecnológico del sistema I+D+I y Programa Estatal de I+D+I orientada a los retos de la sociedad/PID2019-108320RJ-I00/ES/MODULACION DE LA HOMEOSTASIS DEL TRACTO GENITAL DE LA HEMBRA POR EXOSOMAS SEMINALES: ¿MECANISMO ESENCIAL PARA LA FERTILIDAD?/
MINECO/Programa Estatal de promoción del talento y su empleabilidad en I+D+I/IJCI-2015-24380/ES/ /
MICINN/Programa Estatal para impulsar la investigación científico-técnica y su transferencia/PID2022-136561OB-I00/ES/MECANISMOS DE SEÑALIZACION EN ESPERMATOZOIDES EN SISTEMAS IN VITRO: CAPACITACION Y CRIOPRESERVACION, Y SU EFECTO EN EL TRACTO GENITAL DE LA HEMBRA/
FEDER/ / /EU/ /
Program
Sanitat Animal
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