Anti-PD-L1 Immunotherapy of Chronic Virus Infection Improves Virus Control without Augmenting Tissue Damage by Fibrosis
Visualitza/Obre
Autor/a
Casella, Valentina
Cebollada Rica, Paula
González-Cao, María
Güerri-Fernandez, Roberto
Bocharov, Gennady
Meyerhans, Andreas
Data de publicació
2024-05-17ISSN
1999-4915
Resum
Immunotherapy with checkpoint inhibitors, albeit commonly used against tumors, is
still at its infancy against chronic virus infections. It relies on the reinvigoration of exhausted T
lymphocytes to eliminate virus-infected cells. Since T cell exhaustion is a physiological process to
reduce immunopathology, the reinvigoration of these cells might be associated with an augmentation
of pathological changes. To test this possibility, we here analyzed in the model system of chronic
lymphocytic choriomeningitis virus (LCMV)-infected mice whether treatment with the checkpoint
inhibitor anti-PD-L1 antibody would increase CD8 T cell-dependent fibrosis. We show that preexisting spleen fibrosis did not worsen under conditions that increase CD8 T cell functionality
and reduce virus loads suggesting that the CD8 T cell functionality increase remained below its
pathogenicity threshold. These promising findings should further encourage immunotherapeutic
trials against chronic virus infections.
Tipus de document
Article
Versió del document
Versió publicada
Llengua
English
Matèries (CDU)
619 - Veterinària
Pàgines
9
Publicat per
MDPI
Publicat a
Viruses
Citació
Casella, Valentina, Paula Cebollada Rica, Jordi Argilaguet, Enric Vidal, María González-Cao, Roberto Güerri-Fernandez, Gennady Bocharov, and Andreas Meyerhans. 2024. “Anti-PD-L1 Immunotherapy of Chronic Virus Infection Improves Virus Control Without Augmenting Tissue Damage by Fibrosis.” Viruses 16 (5): 799. doi:10.3390/v16050799
Número de l'acord de la subvenció
MICINN/Programa Estatal de generación del conocimiento y fortalecimiento científico y tecnológico del sistema I+D+I/PID2022-141395OB-I00/ES/COORDINACION Y COOPERACION DE CELULAS INMUNES DURANTE INFECCIONES VIRALES AGUDAS Y CRONICAS/
FEDER/ / /EU/ /
Programa
Sanitat Animal
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