Increase in Th17 and T-reg Lymphocytes and Decrease of IL22 Correlate with the Recovery Phase of Acute EAE IN Rat
Visualitza/Obre
Data de publicació
2011-11-07ISSN
1932-6203
Resum
Experimental autoimmune encephalomyelitis (EAE), a well-established model of multiple sclerosis, is characterised by
microglial activation and lymphocyte infiltration. Induction of EAE in Lewis rats produces an acute monophasic disease
characterised by a single peak of disability followed by a spontaneous and complete recovery and a subsequent tolerance
to further immunizations. In the current study we have performed a detailed analysis of the dynamics of different
lymphocyte populations and cytokine profile along the induction, peak, recovery and post-recovery phases in this
paradigm. MBP-injected rats were sacrificed attending exclusively to their clinical score, and the different populations of Tlymphocytes as well as the dynamics of different pro- and anti-inflammatory cytokines were analysed in the spinal cord by
flow cytometry, immunohistochemistry and ELISA. Our results revealed that, during the induction and peak phases, in
parallel to an increase in symptomatology, the number of CD3+ and CD4+ cells increased progressively, showing a Th1
phenotype, but unexpectedly during recovery, although clinical signs progressively decreased, the number and proportion
of CD3+ and CD4+ populations remained unaltered. Interestingly, during this recovery phase, we observed a marked
decrease of Th1 and an important increase in Th17 and T-reg cells. Moreover, our results indicate a specific cytokine
expression profile along the EAE course characterized by no changes of IL10 and IL17 levels, decrease of IL21 on the peak,
and high IL22 levels during the induction and peak phases that markedly decrease during recovery. In summary, these
results revealed the existence of a specific pattern of lymphocyte infiltration and cytokine secretion along the different
phases of the acute EAE model in Lewis rat that differs from those already described in chronic or relapsing-remitting mouse
models, where Th17-cells were found mostly during the peak, suggesting a specific role of these lymphocytes and cytokines
in the evolution of this acute EAE model.
Tipus de document
Article
Versió del document
Versió publicada
Llengua
English
Matèries (CDU)
619 - Veterinària
Pàgines
13
Publicat per
Public Library of Science
Publicat a
PLoS ONE
Citació
Almolda, Beatriz, Manuela Costa, Maria Montoya, Berta González, and Bernardo Castellano. 2011. “Increase in Th17 and T-reg Lymphocytes and Decrease of IL22 Correlate With the Recovery Phase of Acute EAE IN Rat.” PloS One 6 (11): e27473. doi: 10.1371/journal.pone.0027473
Número de l'acord de la subvenció
MICINN/Programa Nacional de Proyectos de Investigación Fundamental/BFU2008-04407/ES/Caracterización de subpoblaciones de células de microglia/macrófagos del CNS que pueden modular la función linfocitaria en microambientes inflamatorios y antiinflamatorios/BFI
MICINN/Programa Nacional de Proyectos de Investigación Fundamental/BFU2011-27400/ES/Implicación de los astrocitos y la microglia en la terminación de la respuesta inmunitaria y el establecimeinto de la tolerancia en diferentes paradigmas/
Programa
Sanitat Animal
Aquest element apareix en la col·lecció o col·leccions següent(s)
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