Endometrial gene expression profile of pregnant sows with extreme phenotypes for reproductive efficiency
Visualitza/Obre
Autor/a
Córdoba, S.
Balcells, I.
Castelló, A.
Ovilo, C.
Noguera, José Luis
Timoneda, O.
Sánchez, A.
Data de publicació
2015-10-05ISSN
2045-2322
Resum
Prolificacy can directly impact porcine profitability, but large genetic variation and low heritability have been found regarding litter size among porcine breeds. To identify key differences in gene expression associated to swine reproductive efficiency, we performed a transcriptome analysis of sows’ endometrium from an Iberian x Meishan F2 population at day 30–32 of gestation, classified according to their estimated breeding value (EBV) as high (H, EBV> 0) and low (L, EBV< 0) prolificacy phenotypes. For each sample, mRNA and small RNA libraries were RNA-sequenced, identifying 141 genes and 10 miRNAs differentially expressed between H and L groups. We selected four miRNAs based on their role in reproduction, and five genes displaying the highest differences and a positive mapping into known reproductive QTLs for RT-qPCR validation on the whole extreme population. Significant differences were validated for genes: PTGS2 (p= 0.03; H/L ratio= 3.50), PTHLH (p= 0.03; H/L ratio= 3.69), MMP8 (p= 0.01; H/L ratio= 4.41) and SCNN1G (p= 0.04; H/L ratio= 3.42). Although selected miRNAs showed similar expression levels between H and L groups, significant correlation was found between the expression level of ssc-miR-133a (p< 0.01) and sscmiR-92a (p< 0.01) and validated genes. These results provide a better understanding of the genetic architecture of prolificacy-related traits and embryo implantation failure in pigs.
Tipus de document
Article
Versió del document
Versió publicada
Llengua
English
Matèries (CDU)
636 - Explotació i cria d'animals. Cria del bestiar i d'animals domèstics
Pàgines
15
Publicat per
Nature Research
Publicat a
Scientific Reports
Citació
Córdoba, S., I. Balcells, A. Castelló, C. Ovilo, J. L. Noguera, O. Timoneda, and A. Sánchez. 2015. "Endometrial Gene Expression Profile Of Pregnant Sows With Extreme Phenotypes For Reproductive Efficiency". Scientific Reports 5 (1). doi:10.1038/srep14416.
Número de l'acord de la subvenció
MEC/ /AGL2004-08368-C03/ES/MAPEO E IDENTIFICACION DE GENES QUE AFECTAN A CARACTERES REPRODUCTIVOS Y DE SUPERVIVENCIA EN PORCINO EN UN CRUCE F2 (MEISHAN X IBERICO), MEDIANTE TECNICAS DE EXPRESION DIFERENCIAL Y GENES CANDIDATOS/GAN
MICINN/Programa Nacional de Proyectos de Investigación Fundamental/AGL2010-22358-C02-01/ES/CARACTERIZACION FUNCIONAL DE MICRORNAS EN PRODUCCION Y SANIDAD PORCINA/
MEC/Programa nacional de medios de transporte/CSD2007-00036/ES/Centro de Genómica Básica y de orientación Agroalimentaria/
Programa
Genètica i Millora Animal
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