Dietary fat source affects metabolism of fatty acids in pigs as evaluated by altered expression of lipogenic genes in liver and adipose tissues
Ver/Abrir
Fecha de publicación
2009-01-01ISSN
1751-7311
Resumen
Little is known about pig gene expressions related to dietary fatty acids (FAs) and most work have been conducted in rodents.
The aim of this study was to investigate how dietary fats regulate fat metabolism of pigs in different tissues. Fifty-six crossbred
gilts (62 6 5.2 kg BW) were fed one of seven dietary treatments (eight animals per treatment): a semi-synthetic diet containing
a very low level of fat (no fat (NF)) and six fat-supplemented diets (ca. 10%) based on barley and soybean meal. The
supplemental fat sources were tallow (T), high-oleic sunflower oil (HOSF), sunflower oil (SFO), linseed oil (LO), blend (FB) (55%
T, 35% SFO and 10% LO) and fish oil (FO) blend (40% FO and 60% LO). Pigs were slaughtered at 100 kg BW and autopsies
from liver, adipose tissue and muscle semimembranousus were collected for qPCR. The messenger ribonucleic acid (mRNA)
abundances of genes related to lipogenesis were modified due to dietary treatments in both liver (sterol regulatory elementbinding protein-1 (SREBP-1), acetyl CoA carboxylase (ACACA) and stearoyl CoA desaturase (SCD)) and adipose tissue (fatty acid
synthase (FASN), ACACA and SCD), but were not affected in semimembranousus muscle. In the liver, the mRNA abundances of
genes encoding lipogenic enzymes were highest in pigs fed HOSF and lowest in pigs fed FO. In adipose tissue, the mRNA
abundances were highest in pigs fed the NF diet and lowest in pigs fed T. The study demonstrated that dietary FAs stimulate
lipogenic enzyme gene expression differently in liver, fat and muscles tissues.
Tipo de documento
Artículo
Versión del documento
Versión publicada
Lengua
English
Materias (CDU)
636 - Explotación y cría de animales. Cría del ganado y de animales domésticos
Páginas
8
Publicado por
Elsevier
Publicado en
Animal
Citación
Duran-Montgé, P., P. K. Theil, C. Lauridsen, and E. Esteve-Garcia. 2009. “Dietary Fat Source Affects Metabolism of Fatty Acids in Pigs as Evaluated by Altered Expression of Lipogenic Genes in Liver and Adipose Tissues.” Animal 3 (4): 535–542. doi: 10.1017/s1751731108003686
Número del acuerdo de la subvención
MEC/Programa nacional de recursos y tecnologías agroalimentarias/RTA03-060-C2-1/ES/Efecto del perfil en ácidos grasos de ración sobre el depósito y distribución de lípidos en el cerdo/
Program
Nutrició Animal
Este ítem aparece en la(s) siguiente(s) colección(ones)
- ARTICLES CIENTÍFICS [2694]
Excepto si se señala otra cosa, la licencia del ítem se describe como http://creativecommons.org/licenses/by-nc-nd/4.0/