Genome Sequence of African Swine Fever Virus BA71, the Virulent Parental Strain of the Nonpathogenic and Tissue-Culture Adapted BA71V
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Autor/a
Rodríguez, Javier M.
Moreno, Leticia Tais
Alejo, Alí
Lacasta, Anna
Salas, María L.
Fecha de publicación
2015-11-30ISSN
1932-6203
Resumen
The strain BA71V has played a key role in African swine fever virus (ASFV) research. It was the first genome sequenced, and remains the only genome completely determined. A large part of the studies on the function of ASFV genes, viral transcription, replication, DNA repair and morphogenesis, has been performed using this model. This avirulent strain was obtained by adaptation to grow in Vero cells of the highly virulent BA71 strain. We report here the analysis of the genome sequence of BA71 in comparison with that of BA71V. They possess the smallest genomes for a virulent or an attenuated ASFV, and are essentially identical except for a relatively small number of changes. We discuss the possible contribution of these changes to virulence. Analysis of the BA71 sequence allowed us to identify new similarities among ASFV proteins, and with database proteins including two ASFV proteins that could function as a two-component signaling network.
Tipo de documento
Artículo
Versión del documento
Versión publicada
Lengua
English
Materias (CDU)
619 - Veterinaria
Páginas
22
Publicado por
Public Library of Science
Publicado en
PLoS ONE
Citación
Rodríguez, Javier M., Leticia Tais Moreno, Alí Alejo, Anna Lacasta, Fernando Rodríguez, and María L. Salas. 2015. "Genome Sequence Of African Swine Fever Virus BA71, The Virulent Parental Strain Of The Nonpathogenic And Tissue-Culture Adapted BA71V". PLOS ONE 10 (11): e0142889. doi:10.1371/journal.pone.0142889.
Número del acuerdo de la subvención
MINECO/ /AGL2013-43998-C2-1-2-R/ES/ /
Program
Sanitat Animal
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