The Role of Viral and Host MicroRNAs in the Aujeszky’s Disease Virus during the Infection Process
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Autor/a
Timoneda, Oriol
Núñez-Hernández, Fernando
Balcells, Ingrid
Muñoz, Marta
Castelló, Anna
Vera, Gonzalo
Pérez, Lester J.
Egea, Raquel
Mir, Gisela
Córdoba, Sarai
Tomás, Anna
Sánchez, Armand
Fecha de publicación
2014-01-24ISSN
1932-6203
Resumen
Porcine production is a primary market in the world economy. Controlling swine diseases in the farm is essential in order to achieve the sector necessities. Aujeszky’s disease is a viral condition affecting pigs and is endemic in many countries of the world, causing important economic losses in the swine industry. microRNAs (miRNAs) are non-coding RNAs which modulates gene expression in animals, plants and viruses. With the aim of understanding miRNA roles during the Aujeszky’s disease virus [ADV] (also known as suid herpesvirus type 1 [SuHV-1]) infection, the expression profiles of host and viral miRNAs were determined through deep sequencing in SuHV-1 infected porcine cell line (PK-15) and in an animal
experimental SuHV-1 infection with virulent (NIA-3) and attenuated (Begonia) strains. In the in vivo approach miR-206, miR-133a, miR-133b and miR-378 presented differential expression between virus strains infection. In the in vitro approach, most miRNAs were down-regulated in infected groups. miR-92a and miR-92b-3p were up-regulated in Begonia infected samples. Functional analysis of all this over expressed miRNAs during the infection revealed their association in pathways related to viral infection processes and immune response. Furthermore, 8 viral miRNAs were detected by stem loop RT-qPCR in both in vitro and in vivo approaches, presenting a gene regulatory network affecting 59 viral genes. Most described viral miRNAs were related to Large Latency Transcript (LLT) and to viral transcription activators EP0 and IE180, and also to regulatory genes regarding their important roles in the host – pathogen interaction during viral infection.
Tipo de documento
Artículo
Versión del documento
Versión publicada
Lengua
English
Materias (CDU)
619 - Veterinaria
Páginas
11
Publicado por
Public Library of Science
Publicado en
PLoS ONE
Citación
Timoneda, Oriol, Fernando Núñez-Hernández, Ingrid Balcells, Marta Muñoz, Anna Castelló, Gonzalo Vera, and Lester J. Pérez et al. 2014. "The Role Of Viral And Host Micrornas In The Aujeszky’S Disease Virus During The Infection Process". Plos ONE 9 (1): e86965. doi:10.1371/journal.pone.0086965.
Número del acuerdo de la subvención
MEC/ /AGL2007-66371-C02/ES/IDENTIFICACION Y CARACTERIZACION DE MICRORNAS VIRICOS QUE AFECTAN AL PORCINO/
MICINN/Programa Nacional de Proyectos de Investigación Fundamental/AGL2010-22358-C02/ES/MICRORNAS EN INFECCIONES VIRICAS DEL CERDO: ANALISIS FUNCIONAL E IMPLICACIONES EN PATOGENIA VIRAL/
Program
Sanitat Animal
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