Association between the pig genome and its gut microbiota composition
Visualitza/Obre
Autor/a
Migura-Garcia, Lourdes
Estellé, Jordi
Criado-Mesas, Lourdes
Revilla, Manuel
Castelló, Anna
Muñoz, María
García-Casco, Juan M.
Fernández, Ana I.
Ballester, Maria
Folch, Josep M.
Data de publicació
2019-06-19ISSN
2045-2322
Resum
The gut microbiota has been evolving with its host along the time creating a symbiotic relationship. In this study, we assess the role of the host genome in the modulation of the microbiota composition in pigs. Gut microbiota compositions were estimated through sequencing the V3-V4 region of the 16S rRNA gene from rectal contents of 285 pigs. A total of 1,261 operational taxonomic units were obtained and grouped in 18 phyla and 101 genera. Firmicutes (45.36%) and Bacteroidetes (37.47%) were the two major phyla obtained, whereas at genus level Prevotella (7.03%) and Treponema (6.29%) were the most abundant. Pigs were also genotyped with a high-throughput method for 45,508 single nucleotide polymorphisms that covered the entire pig genome. Subsequently, genome-wide association studies were made among the genotypes of these pigs and their gut microbiota composition. A total of 52 single-nucleotide polymorphisms distributed in 17 regions along the pig genome were associated with the relative abundance of six genera; Akkermansia, CF231, Phascolarctobacterium, Prevotella, SMB53, and Streptococcus. Our results suggest 39 candidate genes that may be modulating the microbiota composition and manifest the association between host genome and gut microbiota in pigs.
Tipus de document
Article
Versió del document
Versió publicada
Llengua
English
Matèries (CDU)
619 - Veterinària
Pàgines
11
Publicat per
Nature Research
Publicat a
Scientific Reports
Citació
Crespo-Piazuelo, Daniel, Lourdes Migura-Garcia, Jordi Estellé, Lourdes Criado-Mesas, Manuel Revilla, Anna Castelló, and María Muñoz et al. 2019. "Association Between The Pig Genome And Its Gut Microbiota Composition". Scientific Reports 9 (1). Springer Science and Business Media LLC. doi:10.1038/s41598-019-45066-6.
Número de l'acord de la subvenció
MINECO-FEDER/Programa estatal de I+D+I orientada a los retos de la sociedad/AGL2014-56369-C2-2-R/ES//Validación genética y funcional de QTLS, genes y redes génicas y estudio del efecto del microbioma sobre crecimiento, deposición de grasa y calidad de carne en porcino. S2/
MINECO-FEDER/Programa Estatal de I+D+I orientada a los retos de la sociedad/AGL2017-82641-R/ES/Genómica funcional, biología de sistemas y microbiomica aplicadas a la identificación de reguladores genéticos del crecimiento, engrasamiento y calidad de la carne en porcino/
Programa
Genètica i Millora Animal
Sanitat Animal
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