Identification of an Immunosuppressive Cell Population during Classical Swine Fever Virus Infection and Its Role in Viral Persistence in the Host
Visualitza/Obre
Autor/a
Bohorquez, Jose Alejandro
Muñoz-González, Sara
Pérez-Simó, Marta
Revilla, Concepción
Domínguez, Javier
Data de publicació
2019-09-04ISSN
1999-4915
Resum
Classical swine fever virus (CSFV) remains a highly important pathogen, causing major
losses in the swine industry. Persistent infection is highly relevant for CSFV maintenance in the field;
however, this form of infection is not fully understood. An increase in the granulocyte population has
been detected in CSFV persistently infected animals. The aim of this work was to evaluate the possible
immunosuppressive role of these cells in CSFV persistent infection. The phenotype of peripheral blood
and bone marrow cells from persistently infected and naïve animals was evaluated by flow cytometry,
and the capacity of specific cell subsets to reduce the interferon gamma (IFN-γ) response against
unspecific and specific antigen was determined using co-culture assays. The frequency of granulocytic
cells was increased in cells from CSFV persistently infected pigs and they showed a phenotype similar
to immunosuppressive cell populations found in persistent infection in humans. These cells from
persistently infected animals were able to reduce the IFN-γ response against unspecific and specific
antigen. Our results suggest that immature immunosuppressive cell populations play a role in CSFV
persistent infection in swine. The information obtained by studying the role of myeloid derived
suppressor cells (MDSC) during CSFV persistent infection may extrapolate to other viral persistent
infections in mammals.
Tipus de document
Article
Versió del document
Versió publicada
Llengua
English
Matèries (CDU)
619 - Veterinària
Pàgines
15
Publicat per
MDPI
Publicat a
Viruses
Citació
Bohorquez, Muñoz-González, Pérez-Simó, Revilla, Domínguez, and Ganges. 2019. "Identification Of An Immunosuppressive Cell Population During Classical Swine Fever Virus Infection And Its Role In Viral Persistence In The Host". Viruses 11 (9): 822. MDPI AG. doi:10.3390/v11090822.
Número de l'acord de la subvenció
MINECO/Programa estatal de I+D+I orientada a los retos de la sociedad/AGL2015-66907-R/ES/Inmunopatogenia de infecciones persistentes y subclínicas generadas por el virus de la peste porcina clásica/
MINECO/Programa estatal de I+D+I orientada a los retos de la sociedad /RTI2018-100887-B-100/ES/Descifrando nuevos factores virales y del hospedador involucrados en el desarrollo de la peste porcina clásica: implicaciones para el control de la enfermedad/
Programa
Sanitat Animal
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